Our lab is interested in cellular dynamics in animal development. During embryogenesis, cells divide, change their shapes, and migrate to establish highly organized structures. We are investigating how these events are regulated using the nematode Caenorhabditis elegans as a model organism.
||B.Sc., Department of Biophysics and Biochemistry,
Faculty of Science, The University of Tokyo
||Ph.D., Department of Biophysics and Biochemistry,
Graduate School of Science, The University of Tokyo
Fellow, University of Wisconsin-Madison
||Assistant Professor, Department of Biophysics and
Biochemistry, Graduate School of Science, The University of Tokyo
PRESTO, Japan Science and Technology Corporation
||Team Leader, Center for Developmental Biology, RIKEN
||Professor, Graduate School of Life Sciences, Tohoku
For other contributions, please refer to: http://scholar.google.co.jp/citations?user=ZiPNVBoAAAAJ&hl=en
- Kubota Y., Tsuyama K., Takabayashi Y., Haruta N., Maruyama R., Iida N. and Sugimoto A. (2014). The PAF1 complex is involved in embryonic epidermal morphogenesis in Caenorhabditis elegans. Dev Biol 391, 43-53.
- Toya, M., Terasawa, M., Nagata, K., Iida, Y., and Sugimoto, A. (2011). A kinase-independent role for Aurora A in the assembly of mitotic spindle microtubules in Caenorhabditis elegans embryos. Nat Cell Biol 13, 710-716.
- Hanazawa, M., Yonetani, M., and Sugimoto, A. (2011). PGL proteins self associate and bind RNPs to mediate germ granule assembly in C. elegans. J Cell Biol 192, 929-937.
- Motegi, F., Velarde, N.V., Piano, F. & Sugimoto, A. (2006) Two phases of astral microtubule activity during cytokinesis in C. elegans embryos. Dev Cell 10, 509-520.
- Motegi, F. & Sugimoto, A. (2006) Sequential functioning of the ECT-2 RhoGEF, RHO-1 and CDC-42 establishes cell polarity in Caenorhabditis elegans embryos. Nat Cell Biol 8, 978-985.
||The Molecular Biology Society of Japan, Japan Society for Cell Biology, Japanese Society of Developmental Biologists
||Genetics (undergraduate), Molecular Genetics (undergraduate), etc.
We are investigating dynamic cellular events during embryogenesis, including cell division, cell polarity establishment, and cell shape change using the nematode C. elegans as a model system. For experimental approaches, we extensively use high-resolution live microscopy, as well as genetics, cell and molecular biology, biochemistry, and genomics.
Top: The first cell division in C. elegans
; Microtubules (green), chromosomes (red) and centrosomes (yellow). Middle: A one-cell to four-cell stage embryo; Germ granules (green) and chromosomes (red). Bottom: Epidermal morphogenesis.
Cells are filled with mysteries waiting to be solved.