Shapes of organisms are highly variable, yet there are common principles in constructing different body or tissue shapes. Recent study showed that common cellular properties or molecular nature are repeatedly utilized in distinct morphogenetic processes. The goal of my study is to understand how the cellular behaviors common to various morphogenesis are implemented by molecular interactions and how organisms utilize those common principles to build different shapes. I would like to address those questions by using a tiny organism, Drosophila with combination of multi-disciplinary approaches such as genetics, molecular biology and mechanics.
2006 Ph.D. Graduate program in Biophysics
and Biochemistry, Graduate School of Science, the University of Tokyo, Tokyo,
Japan. Prof. Tetsuya Tabata’s lab.
and Dahmann, C.
Dunst, S., and Dahmann, C.
Aigouy, B., Aliee, M, Sui, L., Eaton, S., Jülicher F., and Dahmann, C.
D. and Dahmann,
Umetsu, D.*, Landsberg,
K.*, Farhadifar, R.*, Ranft, J.*, Widmann, T., Bittig, T., Said,
A., Jülicher, F. and Dahmann, C.
Umetsu, D.*, Yasugi, T.*, Murakami, S., Sato, M. and
Murakami, S., Sato, M. and Tabata, T.
Japanese Society of Developmental Biologists, The Molecular Biology of Japan
Tissue boundaries are formed by preventing cell mixing between neighboring cell populations. Boundaries are found not only between tissues but also within a tissue. Those boundaries are used as a landmark that gives cells positional information during tissue patterning. However, how cell mixing is limited at boundaries are unknown. I have been trying to understand the mechanisms by combining genetics, micro-laser dissection, live imaging, quantitative image analysis and computer simulations. We found that mechanical tension on cell junctions is locally increased at the boundaries. The local increase in tension is important for maintaining boundaries. Currently, I am interested in how cells locally increase mechanical tension at boundaries at molecular level. I am also aiming to understand how cells sense physical forces and utilize them during tissue morphogenesis.
One of the most important things in scientific research is to keep asking questions. How can you find good questions? I believe they come from careful observations from daily experiments. Recent advances in microscopy technology and image processing now allow us to observe living organisms at a high resolution that I could not imagine when I was a student. I hope I can help you find your good questions from your own observations of living cells in living tissues.