Department of Developmental Biology and Neurosciences
Division of Developmental Biology

Organogenesis 分野

17器官形成分野 斎藤先生 顔写真(処理後)
Daisuke Saito
キャンパス Aobayama キャンパス
専攻分野 Organogenesis
連絡先 022-795-6691

Living things on the earth transmit genetic information to next generation. So, life goes on. What is the transmitter? The germ cells. The germ cells are extremely special and fascinating even among all of the various cells in the whole body. For example, they are potentially immortal and totipotent. During development, the germ cells are known to migrate the longest distance along unusual pathways, such as the blood vessels and intestine in the embryo. Thus, I am attracted to their mysterious behaviors during development, and research how they migrate. I am also interested in the nature of stemness and of germness, and the evolution of the germ cell. They always fascinate me.


2003 Ph.D (Dr. of Science, Biology)  Tohoku University, Japan
Apr/2003 –Apr/2005 Postdoctoral fellow, RIKEN Center for
Developmental Biology, Japan
May/2005-Mar/2013 Assistant Professor, Graduate School
of Biological Science, Nara Institute of Science and
Technology, Japan
Apr/2013-Dec/2013 Assistant Professor, Department of
Developmental Biology and Neurosciences, Graduate
school of life sciences, Tohoku University
Jan/2014-Present Assistant Professor, Frontier Research
Institute for Interdisciplinary Sciences (FRIS), Tohoku University

  1. Yoshino, T., Saito, D., Atsuta, Y., Uchiyama, C., Ueda, S., Sekiguchi, K. and Takahashi, Y.: Interepithelial signaling with nephric duct is required for the formation of overlying coelomic epithelial cell sheet. Proc. Natl. Acad. Sci. USA 111: 6660-6665, 2014 IF 9.681
  2. Atsuta, Y., Tadokoro, R., Saito, D. and Takahashi, Y.: Transgenesis of the Wolffian duct visualizes dynamic behavior of cells undergoing tubulogenesis in vivo. Dev. Growth Differ. 55: 579-590, 2013 IF 2.210
  3. Saito, D., Takase, Y., Murai, H. and Takahashi, Y.: The dorsal aorta initiates a molecular cascade that instructs sympatho-adrenal specification. Science, 336: 1578-1581, 2012 IF 31.201
  4. Yokota, Y., Saito, D., Tadokoro, R. and Takahashi, Y.: Genomically integrated transgenes are stably and conditionally expressed in neural crest cell-specific lineages. Dev. Biol.353: 382-395, 2011  IF 4.069 
  5. Yoshino, T., Saito, D., Tadokoro, R. and Takahashi, Y.: In vivo gene manipulations of epithelial cell sheets: anovel model to study epithelial-to-mesenchymal transition. Dev. Growth Differ. 53: 378-388, 2011 IF 2.210
  6. Ohata, E., Tadokoro, R., Sato, Y., Saito, D. and Takahashi, Y.: Notch signal is sufficient to direct an endothelial conversion from non-endothelial somitic cells conveyed to the aortic region by CXCR4. Dev. Biol. 335: 33-42, 2009 IF 4.069 
  7. Watanabe, T., Sato, Y., Saito, D., Tadokoro, R. and Takahashi, Y.: EphrinB2 cordinates the formation of a morphological boundary and cell epithelialization during somite segmentation. Proc. Natl. Acad. Sci. USA 106: 7467-7472, 2009 IF 9.681 
  8. Sato, Y., Watanabe, T., Saito, D., Takahashi, T., Yoshida, S., Kohyama, J., Ohata,, E., Okano, H. and Takahashi, Y.: Notch signaling mediates the segmental specification of angioblasts in somites and their directed migration toward the dorsal aorta in avian embryos. Dev. Cell 14: 890-901, 2008 IF 14.030 
  9. Watanabe, T., Saito, D., Tanabe, K., Suetsugu, R., Nakaya, Y., Nakagawa, S. and Takahashi, Y.: Tet-on inducible system combined with in ovo electroporation dissects multiple roles of genes in somitogenesis of chicken embryos. Dev. Biol. 305: 625-636, 2007  IF 4.069 
  10. Saito, D., Yonei-Tamura, S., Takahashi, Y. and Tamura, K.: Level-specific role of paraxial mesoderm in regulation of Tbx5/Tbx4 expression and limb initiation. Dev. Biol.292: 79-89, 2006   IF 4.069 
  11. Tamura, K., Amano, T., Sato, T., Saito, D., Yonei-Tamura, S. and Yajima, H.: Expression of rigf, a member of avian VEGF family, correlates with vascular patterning in the developing chick limb bud. Mechanism of Development 120: 199-209, 2003 IF 2.833 
  12. Saito, D., Yonei-Tamura, S., Kano, K., Ide, H. and Tamura, K.: Specification and determination of limb identity: evidence for inhibitory regulation of Tbx gene expression.Development 129: 211-220, 2002 IF 6.596 
  13. Tamura, K., Kuraishi, R., Saito, D., Masaki, H., Ide, H., and Yonei-Tamura, S.: Evolutionary aspect of positioning and identification of vertebrate limbs. Journal of Anatomy 199: 195-204, 2001 IF 2.370

Japan Society of Developmental Biologists
The Zoological Society of Japan


*Germ cell specification and migration in the embryoHow do germ cells give rise to the egg? How do they migrate through various environments in the embryo/extraembryonic tissues to reach to their final target, the gonad?


If you are interested in cell migration and cell rearrangement during animal morphogenesis, come in and let’s talk.