|専攻分野||Developmental biology, epigenetics|
In my undergraduate days, I handled fish, but since I went on to graduate school, I have been handling mice. By a curious turn of fate, I have always conducted research on germ cells.
Higaki S, Mochizuki K, Baba H, Akashi Y, Yamaha E, Katagiri S, and Takahashi Y. Feasibility of cryopreservation of zebrafish (Danio rerio) primordial germ cells by whole embryo freezing. Japanese Journal of Veterinary Research 57, 119-128 (2009).
Higaki S, Mochizuki K, Akashi Y, Yamaha E, Katagiri S, and Takahashi Y. Cryopreservation of primordial germ cells by rapid cooling of whole zebrafish (Danio rerio) embryos. Journal of Reproduction and Development 56, 212-218 (2010).
Mochizuki K and Matsui Y. Epigenetic profiles in primordial germ cells: Global modulation and fine tuning of the epigenome for acquisition of totipotency. Development, Growth & Differentiation 52, 517-525 (2010).
Mochizuki K, Tachibana M, Saitou M, Tokitake Y and Matsui Y. Implication of DNA demethylation and bivalent histone modification for selective gene regulation in mouse primordial germ cells. PLoS ONE 7, e46036 (2012).
Okamura D, Mochizuki K, Taniguchi H, Tokitake Y, Ikeda M, Yamada Y, Tournier C, Yamaguchi S, Tada T, Schöler HR and Matsui Y. REST and its downstream molecule Mek5 regulate survival of primordial germ cells. Developmental Biology 372, 190-202 (2012).
Kobayashi H, Sakurai T, Miura F, Imai M, Mochizuki K, Yanagisawa E, Sakashita A, Wakai T, Suzuki Y, Ito T, Matsui Y and Kono T. High-resolution DNA methylome analysis of primordial germ cells identifies gender-specific reprogramming in mice. Genome Research 23, 616-627 (2013).
Matsui Y, Mochizuki K. A current view of the epigenome in mouse primordial germ cells. Molecular Reproduction and Development 81, 160-170 (2014).
Japanese Society of Developmental Biologists, The Molecular Biology Society of Japan, The Japan Society for Epigenetics
I am conducting research focused on the epigenetic mechanisms that ensure germ cell development and differentiation and its unique gene expression profile. I want to unravel the framework that makes germ cells, the so-called foundation of life, through the keyhole of epigenetics.
I really get excited when I uncover an interesting life phenomenon that no-one’s ever seen before. Together, let’s aim to be original.