Department of Biomolecular Sciences
Division of Biomolecular Chemistry

Bioactive Molecules 分野

Shinjiro Yamaguchi
キャンパス Katahira キャンパス
専攻分野 Bioactive Molecules
連絡先 022-217-6197

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I was born in 1968 in Tokyo. The Laboratory of Bioactive Molecules was established immediately after the Tohoku Earthquake in April 2011.

The keyword for our research is “plant hormones.” We are interested in combining the strengths of chemistry and biology to reveal how plant hormones are synthesized and how they operate in plants. We endeavor to value our colleagues in the laboratory and enjoy engaging in exciting research. And we aim to be number one in the world.

I encourage anyone interested to give our lab a visit.

Mar. 1993 Graduated from the Department of Agricultural Chemistry, Faculty of Agriculture, The University of Tokyo
Mar. 1993 Completed Master’s program, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Mar. 1996 Completed Doctoral program, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Apr.1996 – Mar. 1997 Researcher, Frontier Research Program, RIKEN
Apr. 1997 – Jun. 2000 Researcher, Biology Department, Duke University (U.S.A.)
Jul. 2000 – Mar. 2005 Researcher, RIKEN Plant Science Center
Apr. 2005 – Mar. 2011 Team Leader, RIKEN Plant Science Center
Mar. 2011 – present Current position
Apr. 2011 – Mar. 2012 Concurrent service as Team Leader, RIKEN Plant Science Center
  1. Seto, Y., Sado, A., Asami K., Hanada, A., Lim, J., Umehara, M., Akiyama, K. & Yamaguchi, S. (2014) Carlactone is an endogenous biosynthetic precursor for strigolactones. Proc Natl Acad Sci U S A., 111: 1640-1645.
  2. Magome, H., Nomura, T., Hanada, A., Takeda-Kamiya N., Ohnishi, T., Shinma, Y., Katsumata, T., Kawaide, H., Kamiya, Y. & Yamaguchi, S. (2013) CYP714B1 and CYP714B2 encode gibberellin 13-oxidase that encode gibberellin activity in rice. Proc Natl Acad Sci U S A., 110: 1947-1952.
  3. Umehara, M., Hanada, A., Magome, H., Takeda-Kamiya, N. & Yamaguchi, S. (2010) Contribution of strigolactones to the inhibition of tiller bud outgrowth under phosphate deficiency in rice. Plant Cell Physiol., 51: 1118-1126.
  4. Tsuchiya, Y,. Vidaurre, D., Toh, S., Hanada. A, Nambara, E., Kamiya, Y., Yamaguchi, S. & McCourt, P. (2010) A small-molecule screen identifies new functions for the plant hormone strigolactone. Nat. Chem. Biol., 6: 741-749.
  5. Umehara, M., Hanada, A., Yoshida, S., Akiyama, K., Arite, T., Takeda-Kamiya, M., Magome, H., Kamiya, Y., Shirasu, K., Yoneyama K., Kyozuka J. & Yamaguchi, S. (2008) Inhibition of shoot branching by new terpenoid plant hormones. Nature, 455: 195-200.
  6. Yamaguchi, S. (2008) Gibberellin metabolism and its regulation. Annu Rev Plant Biol., 59: 225-251.
  7. Oh, E., Yamaguchi, S., Hu, J., Jikumaru, Y., Jung, B., Pail, I., Lee, H., Sun, T.-p., Kamiya, Y., & Choi, G. (2007) PIL5 regulates gibberellin responsiveness by directly binding to the GAI and RGA promoters in Arabidopsis seeds. Plant Cell, 19: 1192-1208.
  8. Yamauchi, Y., Ogawa, M., Kuwahara, A., Hanada, A., Kamiya, Y. & Yamaguchi, S. (2004) Activation of gibberellin biosynthesis and response pathways by low temperature during imbibition of Arabidopsis seeds. Plant Cell, 16: 367-378.
  9. Ogawa, M., Hanada, A., Yamauchi, Y., Kuwahara, Y., Kamiya, Y. & Yamaguchi, S. (2003) Gibberellin biosynthesis and response during Arabidopsis seed germination. Plant Cell, 15: 1591-1604.
所属学会 The Japanese Society of Plant Physiologists The Japanese Society for Chemical Regulation of Plants Japan Society for Bioscience, Biotechnology, and Agrochemistry The Botanical Society of Japan
担当講義 Bioactive Natural Products Chemistry (for 3rd year Faculty of Agriculture students), Advanced Lecture on Bioactive Compounds (for graduate students)


In our previous research, we discovered a new plant hormone called “strigolactone.” Strigolactones are substances derived from carotenoids and are secreted from plant roots. They are known to be involved in the communication with mycorrhizal fungi that assist plant nutrient uptake and, conversely, with root parasitic plants that attach to plants and steal nutrients. We have found that these substances are hormones that control the growth and morphology of the plants themselves. We are interested in revealing how these small molecules regulate plant growth and development in response to environmental changes. In addition, we aim to develop new strategies for stimulating mycorrhizal fungi that assist nutrient uptake and keep root parasitic plants away using strigolactones.


The Laboratory of Bioactive Molecules is a new laboratory established in 2011. What is most important in this laboratory is to enjoy science. We also welcome the ambition to seek new discoveries that will surprise the world. I encourage anyone interested in our research to contact us.