Introduction of our laboratory
Harnessing our various backgrounds in medical sciences, pharmaceutical sciences, engineering, agricultural sciences and immunology, and working together with clinical researchers at Tohoku University Hospital as well as at Graduate School of Medicine on the Seiryo Campus, we are aiming at understanding the mechanisms by which we discriminate between self and non-self and developing novel strategies against immune disorders, through the detailed studies on immunoregulatory receptors such as Fc receptors and multi-ligand leukocyte immunoglobulin-like receptors expressed on immune cells.
Graduated, Faculty of Pharmaceutical Sciences, Okayama University, 1980. Completed doctoral course (PhD), Graduate School of Medicine, Kyoto University, 1986. Researcher, National Cardiovascular Center Research Institute. Assistant Professor, Lecturer, and Associate Professor; Faculty of Engineering; Okayama University. Visiting Investigator, Memorial Sloan-Kettering Cancer Center, New York. Current position since 1997.
Kimura T, Endo S, Inui M, Saitoh S-i, Miyake K, Takai T. Endoplasmic protein Nogo-B (RTN4-B) interacts with GRAMD4 and regulates TLR9-mediated innate immune responses. J. Immunol. in press.
Inui M, Tazawa K, Kishi Y, Takai T. Platelets convert peripheral blood circulating monocytes to regulatory cells via immunoglobulin G and activating-type Fcgamma receptors. BMC Immunol. in press.
Inui M, Hirota S, Hirano K, Fujii H, Sugahara-Tobinai A, Ishii T, Harigae H, Takai T. Human CD43+ B cells are closely related not only to memory B cells phenotypically but also to plasmablasts developmentally in healthy individuals. Int Immunol. 2015 Mar 5. pii: dxv009.
Kanari Y, Sugahara–Tobinai A, Takahashi H, Inui M, Nakamura A, Hirose S, Takai T. Dichotomy in the FcγRIIB deficiency and autoimmune-prone SLAM haplotype clarifies the roles of the Fc receptor in development of autoantibodies and glomerulonephritis. BMC Immunol 15:47 (2014)
Mitsuhashi Y, Nakamura A, Endo S, Takeda K, Yabe-Wada T, Nukiwa T, Takai T. Regulation of plasmacytoid dendritic cell responses by PIR-B. Blood 120: 3256-9. 2012.
Tanaka J, Hirano K, Sakamoto Y, Sugahara-Tobinai A, Endo S, Ito-Matsuoka Y, Nakano A, Inui M, Nitschke L, Takai T. Intravenous immunoglobulin suppresses IL-10 production by activated B cells in vitro. Open J. Immunol. 2(4): 149-160, 2012.
Matsushita H, Endo S, Kobayashi E, Sakamoto Y, Kobayashi K, Kitaguchi K, Kuroki K, Söderhäll A, Maenaka K, Nakamura A, Strittmatter SM, Takai T. Differential but competitive binding of Nogo protein and class I major histocompatibility complex (MHCI) to the PIR-B ectodomain provides an inhibition of cells. J. Biol. Chem. 286(29):25739-47, 2011.
Arita K, Endo S, Kaifu T, Kitaguchi K, Nakamura A, Ohmori H, Kohu K, Satake M, Takai T. Transcriptional activation of the Pirb gene in B cells by PU.1 and Runx3. J. Immunol. 186(12): 7050-9, 2011.
Kubo T, Uchida Y, Watanabe Y, et al.Augmented TLR9-induced Btk activation in PIR-B-deficient B-1 cells provokes excessive autoantibody production and autoimmunity. J. Exp. Med. 206:1971-82 (2009)
Imada M, Masuda M, Satoh R, et al.Ectopically expressed PIR-B on T cells constitutively binds to MHC class I and attenuates T helper type 1 responses.Int. Immu. 21:1151-61 (2009)
Inui M, Kikuchi Y, Aoki N, et al.Signal adaptor DAP10 associates with MDL-1 and triggers osteoclastogenesis in cooperation with DAP12. Proc. Natl. Acad. Sci. USA 106: 4816-21 (2009)
Endo S, Sakamoto Y, Nakamura A, Takai T. Regulation of cytotoxic T lymphocyte triggering by PIR-B on dendritic cells. Proc. Natl. Acad. Sci. USA 105: 14515-20 (2008)
Nakamura A, Kobayashi E, Takai T. Exacerbated graft-versus-host disease in Pirb-/- mice. Nat. Immunol. 5: 623-629 (2004)
Koga T, Inui M, Inoue K, et al.Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis. Nature 428: 758-763 (2004)
Japanese Society for Immunology, Japanese Society of Allergology, Japanese Society of Inflammation and Regeneration, Molecular Biology Society of Japan, Japanese Biochemical Society, American Association of Immunologists
Immunology, School of Medicine; Regenerative Dentistry/Medicine, School of Dentistry; Aging Biology, Faculty of Science; Immunology, Graduate School of Medicine; Cell Biology, Graduate School of Life Sciences.