|専攻分野||Molecular Genetics, Bioinformatics|
Faculty of Science, Tohoku University
Y. Daigaku, A. Keszthelyi, C. A. Müller I. Miyabe, T.
Brooks, R. Retkute, M. Hubank, C. A. Nieduszyski, A. M. Carr, A global profile of replicative polymerase
usage, Nat. Struct. Mol. Biol. 22,
|所属学会||Genetic Society of Japan|
During each cell division, genomic information must be efficiently replicated and subsequently segregated at mitosis. However, the process of replication is not without incident - it is well established that the replication machinery encounters various obstacles and is designed to have a degree of flexibility, allowing cells to tolerate the problem within limited time during S phase. By combining genome-wide analysis of DNA replication with biochemical analysis, my research aim to elucidate the dynamic process underling DNA replication and its influence to integrity of genome information.