Department of Developmental Biology and Neurosciences
Division of Developmental Regulation

Germ Cell Development 分野

yohei hayashi
キャンパス Seiryo キャンパス
専攻分野 Epigenetics
連絡先 +81-22-717-8572

In graduate school, we worked on the elucidation of epigenetic mechanisms for the regulation of gene expression in budding yeast. Currently, I am attracted to study of the germ cells responsible for intergenerational information inheritance. I am interested in how the information possessed by germ cells is changed or inherited through dynamic phenomena such as germ-cell differentiation, fertilization, and ontogeny.

2005 Graduated Faculty of Pharmaceutical Science, University of Tokyo
2010 Completed Graduate School of Science, University of Tokyo
2011 Post-doctoral Fellow, Institute of Molecular and Cellular Biosciences, University of Tokyo
2011-2014 Post-doctoral Fellow, Graduate School of Pharmaceutical Science, University of Tokyo
2014- Current position
  1. Adachi T, Ishii K, Matsumoto Y, Hayashi Y, Hamamoto H, Sekimizu K.
    Niemann-Pick disease type C2 protein induces triglyceride accumulation in silkworm and mammalian cell lines.
    Biochem J., 459, 137-147 (2014).
  2. Kawano A, Hayashi Y, Noguchi S, Handa H, Horikoshi M, Yamaguchi Y.
    Global analysis for functional residues of histone variant Htz1 using the comprehensive point mutant library.
    Genes Cells, 16, 590-607, (2011).
  3. Sato L*, Noguchi S*, Hayashi Y*, Sakamoto M*, Horikoshi M.
    Global analysis of functional relationships between histone point mutations and the effects of histone deacetylase inhibitors.
    Genes Cells, 15, 553-594, (2010) (*equally contributed).
  4. Akai Y*, Adachi N*, Hayashi Y*, Eitoku M, Sano N, Natsume R, Kudo N, Tanokura M, Senda T, Horikoshi M.
    Structure of the histone chaperone CIA/ASF1-double bromodomain complex linking histone modifications and site-specific histone eviction.
    Proc. Natl Acad. Sci. U.S.A., 107, 8153-8158, (2010) (*equally contributed).
  5. Hayashi Y* , Senda T*, Sano N*, Horikoshi M.
    Theoretical framework for the histone modification network: modifications in the unstructured histone tails form a robust scale-free network.
    Genes Cells, 14, 789-806, (2009) (*equally contributed).

The Molecular Biology Society of Japan


In normal development, pluripotent stem cells differentiate into epiblasts, which have limited pluripotency, prior to the differentiation of germ-cells. Therefore, pluripotent stem cells do not directly acquire the nature of germ cells in vivo. Attempts to convert pluripotent stem cells directly into germ cells in vitro are expected to contribute not only to the artificial preparation of germ cells, but also to the understanding of the biological significance of germ-cell differentiation through epiblasts in vivo.


I think the best part of research is the course of setting up a problem on your own, formulating a hypothesis, and solving the problem with logic, experiments, and discussions. It becomes addictive to discover the laws of nature by repeating this process. Please nurture the seeds of your curiosity and grow buds of discovery. Let's grow them together if there is a chance for you to research with me.