|専攻分野||Developmental Biology, Molecular Cellular Biology, Genetics|
When I was a graduated student, I studied molecular mechanisms of the migration pattern of neural crest, a vertebrate-specific embryonic tissue.
From 2001, I am studying molecular mechanisms of morphogenesis using the nematode C. elegans, which is a model organism that can be adopted for molecular, cellular, and genetic approaches. My current efforts are aimed at figuring out the evolutionally conserved molecular/genetic network that is required for regulation of cell behavior during development.
1991: B.Sc., Department of Biology, Faculty of Science, Kanazawa University
Kubota Y., Tsuyama K., Takabayashi Y., Haruta N., Maruyama R., Iida N., Sugimoto A. (2014) The PAF1 complex is involved in embryonic epidermal morphogenesis in Caenorhabditis elegans. Dev Biol 39, 43-53
Kim HS. et al., (2014) The novel secreted factor MIG-18 acts with MIG-17/ADAMTS to control cell migration in Caenorhabditis elegans. Genetics 196, 471-479
Doi M. et al., (2013) The novel Rac effector RIN-1 regulates neuronal cell migration and axon pathfinding in C. elegans. Development 140, 3435-3444
Kubota Y., Nagata K., Sugimoto A., Nishiwaki K. (2012) Tissue architecture in the Caenorhabditis elegans gonad depends on interactions among fibulin-1, type IV collagen and the ADAMTS extracellular protease. Genetics 190, 1379-1388
Kubota Y., Ohkura K. et al., (2008) MIG-17/ADAMTS controls cell migration by recruiting nidogen to the basement membrane in C. elegans. PNAS 105, 20804-20809
Nishiwaki K. and Kubota Y. (2007) Role of the basement membrane in cell migration. In "principles of Developmental Genetics", ed. Sally Moody (Academic Press, USA) pp.404-423
Kubota Y. et al., (2006) The conserved oligomeric Golgi complex acts in organ morphogenesis via glycosylation of an ADAM protease in C. elegans. Development 133, 263-274
Kubota Y. et al., (2004) A fibulin-1 homolog interacts with an ADAM protease that controls cell migration in C. elegans. Curr Biol 4, 2011-2018
Nishiwaki K. et al., (2004) An NDPase links ADAM protease glycosylation with organ morphogenesis in C. elegans. Nat Cell Biol 6, 31-37
Kubota Y and Ito K (2000) Chemotactic migration of mesencephalic neural crest cells in the mouse. Dev Dyn 217, 170-179
|所属学会||The Molecular Biology Society of Japan, Japanese Society of Developmental Biology, The Zoological Society of Japan, Japan Matrix Club|
|担当講義||Exercises in Biology, Practical Training in Molecular Biology, Practical Training in Fundamental Biology|