2015年8月28日開催
[単位認定セミナー]Coupling of growth with nutritional status: the roles of novel 佐野浩子博士(久留米大学 分子生命科学研究所)

タイトル

Coupling of growth with nutritional status: the roles of novel

開催日 2015年8月28日(金) 16:00~17:00
開催場所

東北大学大学院生命科学研究科(片平キャンパス)
生命科学プロジェクト総合研究棟1階 105講義室

講師

佐野浩子博士(久留米大学 分子生命科学研究所)

内容
Abstract:

Animals need to coordinate growth with nutritional availability for proper
development and physiology, which leads to better survival. Nutritional
information is mostly perceived by peripheral organs, particularly metabolic
organs such as adipose tissue and gut, before being relayed to the brain,
which modulates physiological responses. Hormonal signaling ensures this
organ-to-organ communication, and defects in this endocrine regulation in
humans often cause diseases including obesity and diabetes. Here we show
that Drosophila peptide hormone, CCHamide-2 (CCHa2) plays important roles in
the coupling of growth with nutritional status.

CCHa2 is a 13-amino acid peptide, which is predominantly expressed in
adipose tissue (the “fat body”) and gut. The expression of CCHa2 is
nutrient-dependent; it is particularly sensitive to glucose. The CCHa2
peptide signals to neuroendocrine cells in the brain that produce Drosophila
insulin-like peptides (Dilps) through its receptor (CCHa2-R) and promotes
the production of Dilps. Dilps are equivalent to mammalian insulin/IGF,
which control tissue growth as well as sugar metabolism. Mutants of both
CCHa2 and CCHa2-R display severe growth retardation during larval stages.
These results demonstrate that CCHa2 and CCHa2-R functionally connect
peripheral tissues with the brain, and that CCHa2/CCHa2-R signaling
coordinates the animal’s growth with its nutritional conditions by
regulating the production of insulin-like peptides.
連絡先
Contact:
Division of Neurogenetics,
Prof. Dr. Daisuke Yamamoto
022-217-6220
(代理 佐藤耕世)

Twitter @TohokuU_Lifesci