Today, we live in an era where the human genome has been decoded, revealing what proteins are expressed in our bodies. Recently, we're even beginning to understand the three-dimensional structures these proteins adopt. However, to truly comprehend human diseases and the mechanisms of life itself, we must understand how proteins actually behave within living systems—and here, many mysteries remain unsolved.
For instance, crucial questions persist: What kinds of post-translational modifications do proteins undergo after being synthesized from DNA and RNA? Which proteins interact with each other, and under what circumstances? Much of this dynamic protein landscape remains unexplored. To tackle these challenging biological questions that cannot be easily addressed through traditional biological approaches alone, we take a unique strategy—developing innovative tools grounded in organic chemistry.
Proteomics is the comprehensive study of all proteins present in an organism, encompassing both the scientific field and the technologies used to analyze them. Our research group integrates cutting-edge chemical methodologies with biological systems, aiming to observe and control protein states within living cells and organisms.