Experimental Immunology
The focus of our work is to find out novel immune regulatory systems, involving regulatory receptors and the associating signaling molecules, and translate them to the clinic. Our research programs include development of novel gene-targeted mice, generation of novel animal models for human diseases, dissection of relationships between receptors and diseases, finding novel receptors, their ligands, and signal molecules involved in regulation, and investigation of regulatory systems in humans, all of which lead to translational medicine. Elucidation of the detailed cascades of the regulation should be valuable to develop novel therapies for allergic, autoimmune, inflammatory, and infectious diseases and cancer, as well as for transplantation.