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Fields

Integrative Life Sciences :
Cooperative faculties

Research

Experimental Immunology

JAPANESE

Experimental Immunology

The focus of our work is to find out novel immune regulatory systems, involving regulatory receptors and the associating signaling molecules, and translate them to the clinic. Our research programs include development of novel gene-targeted mice, generation of novel animal models for human diseases, dissection of relationships between receptors and diseases, finding novel receptors, their ligands, and signal molecules involved in regulation, and investigation of regulatory systems in humans, all of which lead to translational medicine. Elucidation of the detailed cascades of the regulation should be valuable to develop novel therapies for allergic, autoimmune, inflammatory, and infectious diseases and cancer, as well as for transplantation.

Research Overview

  • We found for the first time a series of immune regulatory receptors and demonstrated their significance in preventing immune disorders
  • We have developed a series of immunoreceptor gene-targeted mice
  • Over 100 times we have provided our research materials to investigators worldwide
  • We have prepared in vitro and in vivo experimental systems and know-hows for monitoring immune regulation
  • We have been collaborating several clinical laboratories and pharmaceutical companies for developing new drugs targeting to immune regulatory receptors and the related molecules
URLs http://www2.idac.tohoku.ac.jp/dep/expimmu/

Faculty Members

Professor TAKAI Toshiyuki
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  • Understanding the molecular mechanisms by which we discriminate between immunological self and non-self based on analysis of immunoregulatory receptors on various cells such as B cells. Roles of immunoregulatory receptors in allergy, autoimmune disease, transplantation, and cancer. Development of novel strategies against these immune disorders. (Lecturer: Masanori Inui; Assistant Professor: Shota Endo)

Research