Cell cycle is the process when a cell grows and divide into two identical cells.
We, multicellular organisms are composed of cellular population which is originated from one fertilized egg. These cells share the same genome, but differentiate into different cell types, and as a whole exist as individuals. Diseases or disorders are defined as consequences of failure in differentiation or response to environmental factors induced by various environmental and genetic factors.
In our laboratory, we explore molecules related to cell proliferation, differentiation and oncogenesis, and try to elucidate their molecular functions. We approach from two directions to solve these questions. First, we focus molecules which have been expected to function as cellular proliferation, differentiation or pathogenesis, and analyze them to figure out their molecular mechanisms how they play their roles in cell or in body. Second, we analyze comprehensively human samples, especially human cancer samples, and find new disease-related genes or disease-related molecular network. As it is difficult to show causal relationship, we make all kinds of efforts to obtain convincing data. In both approach, using biochemical or cell biological methods flexibly we try to indicate the molecular mechanisms, and simultaneously we validate these functions are executed in vivo by using disease-model mice.