Molecular and Chemical Life Science :
Microbial Evolution and Function Research


Lecturer YANO Hirokazu
Campus Katahira campus
Laboratory Microbial Evolution and Function Research
Tel +81-22-217-5682
E-mail yano.hirokazu@ige.tohoku.ac.jp
Website https://sites.google.com/view/hirokazuyano/home

Google Scholar

Born in Soraku-gun (current Kizugawa) in Kyoto prefecture. I have many home-towns: Sendai Miyagi, Moscow Idaho, Kotoku Tokyo, and Tsukuba Ibaraki.
2008             Ph.D. Life Science, Tohoku University
2008-2012   Postdoctoral fellow, University of Idaho
2012-2016   Project researcher (2013- project assistant professor), University of Tokyo
2016-2017   Researcher, University of Tsukuba
2017-            Lecturer, Tohoku University
Selected Publications
  • Yano H, Alam MZ, Rimbara E, Shibata TF, Fukuyo M, Furuta Y, Nishiyama T, Shigenobu S, Hasebe M, Toyoda A, Suzuki Y, Sugano S, Shibayama K, Kobayashi I. Networking and specificity-changing DNA methyltransferases in Helicobacter pylori. Front Microbiol. (2020) in press
  • Yano H, Suzuki H, Maruyama F, and Iwamoto T. The recombination-cold region as an epidemiological marker of recombinogenic opportunistic pathogen Mycobacterium avium. BMC Genomics. 20: 752 (2019). 
  • Yano H, Shintani M, Tomita M, Suzuki H, and Oshima T. Reconsidering plasmid maintenance factors for computational plasmid design. Comput. Struct. Biotechnol. J. 17: 70-81 (2019).
  • Nonaka L, Yamamoto T, Maruyama F, Hirose Y, Onishi Y, Kobayashi T, Suzuki S, Nomura N, Masuda M, and Yano H. Interplay of a non-conjugative integrative element and a conjugative plasmid in the spread of antibiotic resistance via suicidal plasmid transfer from an aquaculture Vibrio isolate. PLoS ONE. 13: e0198613 (2018).
  • Miyazaki R*. Yano H*. Sentchilo V. and Van der Meer JR. Physiological and transcriptome changes induced by Pseudomonas putida acquisition of an integrative and conjugative element. Sci. Rep. 8: 5550 (2018) * Equal contribution.
  • Yano H, Iwamoto T, Nishiuchi Y, Nakajima C, Starkova DA, Mokrousov I, Narvskaya O, Yoshida S, Arikawa K, Nakanishi N, Osaki K, Nakagawa I, Ato M, Suzuki Y, and Maruyama F. Population structure and local adaptation of MAC lung disease agent Mycobacterium avium subsp. hominissuis. Genome Biol. Evol. 9: 2403-2417 (2017).
  • Zhang Y, Matsuzaka T, Yano H, Furuta Y, Nakano T, Ishikawa K, Fukuyo M, Takahashi N, Suzuki Y, Sugano S, Ide H, and Kobayashi I. Restriction glycosylases: involvement of endonuclease activities in the restriction process.  Nucleic Acids Res. 45: 1392-1403 (2017). 
  • Yano H, Wegrzyn K, Loftie-Eaton W, Johnson J, Deckert GE, Rogers LM, Konieczny I, and Top EM. Evolved plasmid-host interactions reduce plasmid interference cost. Mol. Microbiol. 101:743-756 (2016). 
  • Loftie-Eaton W, Yano H, Burleigh S, Simmons RS,Hughes JM, Rogers LM, Hunter SS., Settles LM, Forney LJ, Ponciano JM, and Top EM. Evolutionary paths that expand plasmid host-range: implications for spread of antibiotic resistance. Mol. Biol. Evol. 33: 885-897 (2016). 
  • Yano H, Rogers LM, Molly K, Heuer H, Smalla K, Brown CJ, and Top EM. Diversification of host range within the IncP-1 plasmid group. Microbiology. 159: 2303-2315 (2013). 
  • Yano H, Genka H, Ohtsubo Y, Nagata Y, Top EM, and Tsuda M. Cointegrate-resolution of toluene-catabolic transposon Tn4651: determination of crossover site and the segment required for full resolution activity. Plasmid 69: 24-35 (2013). 
  • Yano H, Deckert GE, Rogers LM, and Top EM. Roles of long and short replication initiation proteins in the fate of broad host range IncP-1 plasmids. J. Bacteriol. 194: 1533-1543 (2012).
  • Sota M*, Yano H*, Hughes JM, Daughdrill GW, Abdo Z, Forney LJ, and Top EM. Shifts in host range of a promiscuous plasmid through parallel evolution of its replication initiation protein. ISME J. 4: 1568-1580 (2010). *Equal contribution
  • Yano H, Miyakoshi M, Ohshima K, Tabata M, Nagata Y, Hattori M, and Tsuda M. Complete nucleotide sequence of TOL plasmid pDK1 provides evidence for evolutionary history of IncP-7 catabolic plasmids. J. Bacteriol. 192: 4337-4347 (2010).
Activities in Academic Societies
Society of Genome Microbiology, Japan, American Society for Microbiology

Recent Activities

I am interested in understanding how genetic entities called species are maintained or change in unicellular organisms by studying population evolution and survival strategy of bacteria. My research addresses fundamental questions regarding roles of genome methylation, sexual reproduction in prokaryotes, and molecular mechanisms that support persistence of mobile DNA in cell population. In my projects, I deal with human pathogens Helicobacter pylori and nontuberculous mycobacteria (Mycobacterium avium), and free-living bacteria belonging to genus Pseudomonas or Sphingobium. I use experimental evolution, NGS technologies, bioinformatics, biochemistry and molecular genetics techniques.

Message to Students

Let’s propose new biological concepts based on your original findings. I welcome students who are interested in horizontal gene transfer and environmental microbiology.