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Our lab has just started since April 2018. We are interested in the function of intracellular organelles, in particular, the function of organelle membranes.
Professor TAGUCHI Tomohiko
| Campus | Aobayama campus |
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| Laboratory |
Organelle Pathophysiology
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| Tel | +81-22-795-6676 |
| tomohiko.taguchi.b8＠tohoku.ac.jp |
| Career |
1992
B.Sc., Department of Biophysics and Biochemistry, Faculty of Science, The University of Tokyo 1997
Ph.D., Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo 1997-1999
Postdoctoral Fellow, RIKEN (Institute of Physical and Chemical Research) 1999-2004
Postdoctoral Fellow, Yale University School of Medicine 2004-2008
Associate Professor, Osaka University Graduate School of Medicine 2008-2010
Senior Research Officer, The University of Queensland 2011-2018
Associate Professor, The University of Tokyo 2018-Present
Professor, Tohoku University |
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| Selected Publications |
1. Hansen, A. L., Buchan, G. J., Rühl, M., Mukai, K., Salvatore, S. R., Ogawa, E., Andersen, S., Iversen, M. B., Thielke, A. L., Gunderstofte, C., Motwani, M., Møller, C. T., Jakobsen, A., Fitzgerald, K. A., Roos, J., Lin, R., Maier, T. J., Goldback-Mansky, R., Miner, C. A., Qian, W., Miner, J., Rigby, R. E., Rehwinkel, J., Jakobsen, M. R., Arai, H., Taguchi, T., Schopfer, F. J., Olagnier, D., and Holm, C. K. (2018). Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling.
Proc. Natl. Acad. Sci. U S A 115, E7768-E7775.
DOI: 10.1073/pnas.1806239115 2. Matsudaira, T., Mukai, K., Noguchi, T., Hasegawa, J., Hatta, T., Iemura, S. I., Natsume, T., Miyamura, N., Nishina, H., Nakayama, J., Semba, K., Tomita, T., Murata, S., Arai, H., and Taguchi, T. (2017). Endosomal phosphatidylserine is critical for the YAP signalling pathway in proliferating cells.
Nat Commun 8, 1246.
DOI: 10.1038/s41467-017-01255-33. Mukai, K., Konno, H., Akiba, T., Uemura, T., Waguri, S., Kobayashi, T., Barber, G. N., Arai, H., and Taguchi, T. (2016). Activation of STING requires palmitoylation at the Golgi.
Nat Commun 7, 11932.
DOI: 10.1038/ncomms11932
4. Lee, S., Uchida, Y., Wang, J., Matsudaira, T., Nakagawa, T., Kishimoto, T., Mukai, K., Inaba, T., Kobayashi, T., Molday, R. S., Taguchi, T., and Arai, H. (2015). Transport through recycling endosomes requires EHD1 recruitment by a phosphatidylserine translocase.
EMBO J. 34, 669-688.
DOI: 10.15252/embj.201489703
5. Maekawa, M., Terasaka, S., Mochizuki, Y., Kawai, K., Ikeda, Y., Araki, N., Skolnik, E. Y., Taguchi, T., and Arai, H. (2014). Sequential breakdown of 3-phosphorylated phosphoinositides is essential for the completion of macropinocytosis.
Proc. Natl. Acad. Sci. U S A 111, E978-87.
DOI: 10.1073/pnas.13110291116. Uchida, Y., Hasegawa, J., Chinnapen, D., Inoue, T., Okazaki, S., Kato, R., Wakatsuki, S., Misaki, R., Koike, M., Uchiyama, Y., Iemura, S., Natsume, T., Kuwahara, R., Nakagawa, T., Nishikawa, K., Mukai, K., Miyoshi, E., Taniguchi, N., Sheff, D., Lencer, W. I., Taguchi, T., and Arai, H. (2011). Intracellular phosphatidylserine is essential for retrograde membrane traffic through endosomes.
Proc. Natl. Acad. Sci. U S A 108, 15846-15851.
DOI: 10.1073/pnas.1109101108
7. Low, P. C., Misaki, R., Schroder, K., Stanley, A. C., Sweet, M. J., Teasdale, R. D., Vanhaesebroeck, B., Meunier, F. A., Taguchi, T., and Stow, J. L. (2010). Phosphoinositide 3-kinase delta regulates membrane fission of Golgi carriers for selective cytokine secretion.
J. Cell Biol. 190, 1053-1065.
8. Misaki, R., Morimatsu, M., Uemura, T., Waguri, S., Miyoshi, E., Taniguchi, N., Matsuda, M., and Taguchi, T. (2010). Palmitoylated Ras proteins traffic through recycling endosomes to the plasma membrane during exocytosis.
J. Cell Biol. 191, 23-29.
DOI: 10.1083/jcb.200911143 9. Hieda, M., Isokane, M., Koizumi, M., Higashi, C., Tachibana, T., Shudou, M., Taguchi, T., Hieda, Y., and Higashiyama, S. (2008). Membrane-anchored growth factor, HB-EGF, on the cell surface targeted to the inner nuclear membrane.
J. Cell Biol. 180, 763-769.
DOI: 10.1083/jcb.200710022
10. Ang, A. L., Taguchi, T., Francis, S., Folsch, H., Murrells, L. J., Pypaert, M., Warren, G., and Mellman, I. (2004). Recycling endosomes can serve as intermediates during transport from the Golgi to the plasma membrane of MDCK cells.
J. Cell Biol. 167, 531-543.
DOI: 10.1083/jcb.200408165 11. Mitra, K., Ubarretxena-Belandia, I., Taguchi, T., Warren, G., and Engelman, D. M. (2004). Modulation of the bilayer thickness of exocytic pathway membranes by membrane proteins rather than cholesterol.
Proc. Natl. Acad. Sci. U S A 101, 4083-4088.
12. Seemann, J., Pypaert, M., Taguchi, T., Malsam, J., and Warren, G. (2002). Partitioning of the matrix fraction of the Golgi apparatus during mitosis in animal cells.
Science 295, 848-851.
DOI: 10.1126/science.1068064 |
| Activities in Academic Societies |
Japanese Biochemical Society, Japan Society for Cell Biology, The Japanese Conference on the biochemistry of lipids
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| Teaching |
Cell Biology (undergraduate), Life Science A (undergraduate), etc.
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Recent Activities
* We revealed that STING, an essential protein for the type I interferon response against cytosolic DNA, is activated at the Golgi. The activation requires palmitoylation of STING. Our results may lead to new treatments for cytosolic DNA-triggered autoinflammatory diseases.
Please see Mukai et al., Nat Commun 2016 for the details.
Please see Mukai et al., Nat Commun 2016 for the details.
* We developed a novel method to identify organelle-resident proteins, which is based on the proximity-dependent biotin identification method.
Please see Matsudaira et al., Nat Commun 2017 for the details.
Please see Matsudaira et al., Nat Commun 2017 for the details.