Molecular and Chemical Life Science :
Chemical Biology


Assistant Professor TAKAHASHI Daiki
Campus Katahira campus
Laboratory Analytical Bioorganic Chemistry
Tel +81-22-217-6203
E-mail daiki.takahashi.d4@tohoku.ac.jp
Website https://www.agri.tohoku.ac.jp/bunseki/index-j.html
Education: B.S. Faculty of Agriculture and Life Science, Hirosaki University (2013), Graduate School of Life Sciences, Tohoku University (2019, PhD)
Research Experience: Assis. Prof., Tohoku University (2020-)
Selected Publications
p62 Phase-Separation as the Foundation of Autophagy-Based Degraders.
Daiki Takahashi, Hirokazu Arimoto
Biochemistry 62 559-560 (2022)
Selective autophagy as the basis of autophagy-based degraders.
Daiki Takahashi, Hirokazu Arimoto
Cell Chem. Biol. 28 1061-1071 (2021)
Targeting selective autophagy by AUTAC degraders.
Daiki Takahashi, Hirokazu Arimoto
Autophagy 16 765-766 (2020)
AUTACs: Cargo-Specific Degraders Using Selective Autophagy.
Daiki Takahashi, Jun Moriyama, Tomoe Nakamura, Erika Miki, Eriko Takahashi, Ayami Sato, Takaaki Akaike, Kaori Itto-Nakama, Hirokazu Arimoto
Molecular Cell 76 797-810 (2019)
8-Nitro-cGMP: A Novel Protein-Reactive cNMP and Its Emerging Roles in Autophagy.
Daiki Takahashi, Hirokazu Arimoto
Handb. Exp. Pharmacol. 238 253-268 (2017)
Activities in Academic Societies
Memberships: The Chemical Society of Japan, Japanese Society for Chemical Biology, The Japanese Biochemical Society
Laboratory experiment

Recent Activities

1.    AUTACs: cargo-specific degraders using selective autophagy
Clinical drugs in use today are small molecule inhibitors of disease-related molecules. In contrast, a method that removes (degrades) these molecules is a fundamental therapy. We have developed a compound (AUTAC: autophagy-targeting chimera) that induces targeted degradation of disease-related proteins or organelles via autophagy. AUTAC is the first drug that degrades organelles. Our research is attracting attention from pharmaceutical industry worldwide. 

2.    Elucidation of the mechanism of substrate-specific autophagy 
AUTAC is designed based on "S-guanylation" a marker of autophagic degradation. However, it is not clear how AUTAC induces autophagy. Therefore, we are working to elucidate this mechanism using chemical biology methods. It is very exciting to unravel new mechanisms that support biological activities, and we believe that we can create the next generation of AUTAC based on these new mechanisms.

Message to Students

Let's enjoy research together! We are looking forward to your visit to our laboratory.