GO TOP

Field

Molecular and Chemical Life Science :
Genome Informatics

Research

JAPANESE
Visiting Associate Professor YAMAKAWA Hisashi
Campus Kazusa DNA campus
Laboratory Omics and Imformatics
Tel +81-438-52-3919
E-mail yamakawa＠kazusa.or.jp
Website http://www.kazusa.or.jp
Career
Ph.D. (Doctor of Science, School of Science, The University of Tokyo) (Mar 1994)
Research Scientist, Kazusa DNA Research Institute (Apr 1995 to present)
 
Selected Publications
  1. High-throughput construction of ORF clones for production of the recombinant proteins. Yamakawa H (2009), Methods in molecular biology (Clifton, N.J.) 577 25-39
  2. A simple and robust method for preparation of cDNA nylon microarrays. Yamakawa　 H, Yokoyama S, Hirano T, Kitamura H, Ohara O (2004), DNA Research 11(5) 353-360
  3. Comparison of mRNA and protein levels of four members of the protein 4.1 family: The type II brain 4.1/4.1B/KIAA0987 is the most predominant member of the protein 4.1 family in rat brain. Yamakawa H, Ohara O (2000), Gene 248(1-2) 137-145
  4. Molecular characterization of a new member of the protein 4.1 family (brain 4.1) in rat brain. Yamakawa H, Ohara R, Nakajima D, Nakayama M, Ohara O (1999), Mol. Brain Res. 70(2) 197-209
  5. A DNA cycle sequencing reaction that minimizes compressions on automated fluorescent sequencers. Yamakawa H, Ohara O (1997), Nucl Acids Res 25(6) 1311-1312
  6. Sequence-dependent DNA separation by anion-exchange high-performance liquid chromatography. Yamakawa H, Higashino KI, Ohara O (1996), Anal Biochem 240(2) 242-250
  7. Identification of sequence motifs causing band compressions on human cDNA sequencing. Yamakawa H, Nakajima D, Ohara O (1996), DNA Research 3(2) 81-86 
Activities in Academic Societies
The Biophysical Society of Japan, The Japanese Biochemical Society, The Molecukar Biology Society of Japan, The Ecological Society of Japan, The eDNA Society
Teaching
Advanced Molecular and Chemical Life SciencesⅢ

Recent Activities

Recently, I have been involved in a new environmental measurement technology called environmental DNA analysis. By analyzing trace amounts of DNA left in the environment, it has become possible to relatively easily obtain vast amounts of species habitat information that was previously not possible using traditional ecological approaches. In addition to methods for collecting samples, analysis methods, and bioinformatic approach to obtain more accurate and reliable information, new perspectives have also been added, such as how to extract useful information from big data. So, it is a hot field that is being discussed and examined from various angles, and attracts researchers and practitioners from various positions. We are working on ways to quickly obtain large amounts of reliable data by utilizing the powerful sequencing facilities of the Kazusa DNA Research Institute.

Message to Students

Under ‘study the structure and function of DNA’ as our keyword, we are proceeding with more comprehensive structural and functional analyzes of various genes/genomes, from basic sequence analysis to applications, as well as proteome and metabolome analysis. In addition, we are improving conventional methods, examining cutting-edge analysis methods, and developing new analysis methods. We especially welcome those who are interested in method development.

Research