Molecular and Chemical Life Science :
Multilevel Biomolecular Structure and Dynamics


Associate Professor MATSUI Toshitaka
Campus Katahira campus
Laboratory Biofunctional Chemistry and Nanobiotechnology
Tel +81-22-217-5117
E-mail toshitaka.matsui.d5@tohoku.ac.jp
Website http://www2.tagen.tohoku.ac.jp/lab/mizukami/

Graduated Faculty of Engineering, Kyoto University; completed master’s program, Graduate School of Engineering, Kyoto University.

Completed doctoral program, Department of Mathematical and Physical Sciences Graduate University for Advanced Studies

Achieved current position after serving as a postdoctoral fellow, JSPS; a Research Assistant, Institute for Chemical Reaction Science, Tohoku University; and as a Research Assistant and Lecturer, Institute of Multidisciplinary Research for Advanced Materials, Tohoku University

Selected Publications
  1. Reaction intermediates in the heme degradation reaction by HutZ from Vibrio cholera
    T. Uchida, S. Sekine, N. Dojun, A. Lewis-Ballester, I. Ishigami, T. Matsui, S. Yeh, K. Ishimori
    Dalton Trans. (2017) 46, 8104-8109.
  2. Unique coupling of mono- and dioxygenase chemistries in a single active site promotes heme degradation
    T. Matsui, S. Nambu, C. W. Goulding, S. Takahashi, H. Fujii, M. Ikeda-Saito
    Proc. Natl. Acad. Sci. (2016) 113, 3779-84.
  3. Artificial Hydrogenases based on Cobaloximes and Heme Oxygenase
    M. Bacchi, E. Veinberg, M. J. Field, J. Niklas, T. Matsui, D. M Tiede, O. G. Poluektov, M. Ikeda-Saito, M. Fontecave V. Artero
    ChemPlusChem (2016) 81, 1083-1089.
  4. Charge-state-distribution analysis of Bach2 intrinsically disordered heme binding
    T. Suenaga, M. Watanabe-Matsui, H. Shima, T. Matsui, M. Ikeda-Saito, K. Igarashi, K. Murayama
    J. Biochem. (2016) 160, 291-298.
  5. A new way to degrade heme: The Mycobacterium tuberculosis enzyme MhuD catalyzes heme degradation without generating CO”
    Nambu, S., Matsui, T., Goulding, C. W., Takahashi, S., and Ikeda-Saito, M.
    J. Biol. Chem. (2013) 288, 10101-10109.
Activities in Academic Societies

The Chemical Society of Japan, the Japanese Biochemical Society, Society of Biological Inorganic Chemistry


Biology B (General Education), Biochemistry IIA (AMC)

Recent Activities

  • Elucidation of oxygen activation chemistry of metalloenzymes
  • New mechanism and biological function of heme degradation
  • Development of mechanism-based drugs

Message to Students

Try hard and enjoy your research, study and school life in Tohoku university.