Molecular and Cellular Biology
Graduated from the Graduate School of Science of Tohoku University and worked as an assistant professor in the Laboratory of Molecular Biology in the Graduate School of Medicine of Tohoku University and as a visiting scientist at Laboratory of Cell Biology in National Cancer Institute of National Institutes of Health in the U.S. before my present position.
Yasumoto, K. et al., Role of the intracellular localization of HIF-prolyl hydroxylases. Biochim. Biophys. Act - Mol. Cell Res., 1793, 792-797 (2009) Hiwatashi, Y. et al., PHD1 interacts with ATF4 and negatively regulates its transcriptional activity without prolyl hydroxylation. Exp. Cell Res., 317, 2789-2799 (2011)
|Activities in Academic Societies||
Japanese Biochemical Society, The Molecular Biology Society of Japan, Japan Cancer Association, Japanese Society for Pigment Cell Research
Understanding the molecular mechanisms of cellular response to hypoxic stress. It has been reported that the enzymatic activity of HIF-prolyl hydroxylases, PHDs, depends upon oxygen concentration, and regulates cellular hypoxic responses. My interest is how the activity of PHDs is modified by several factors involved in other stress responses, such as endoplasmic reticular (ER) or osmotic stress.