My research interests include the total synthesis of structurally complex natural marine products and the design of biologically important molecules.
Makoto Sasaki graduated from the Department of Chemistry, Faculty of Science, the University of Tokyo in 1984. He received M.Sc. (1986) and Ph.D. (1989) degrees in Chemistry from the School of Science, the University of Tokyo. After working as a researcher at the National Chemical Laboratory for Industry, he joined the Faculty of Science, the University of Tokyo as an Assistant Professor in the research group of Professor Kazuo Tachibana in 1991 and then was promoted to a Lecturer in 1999. In 2001, he moved to the Graduate School of Life Sciences, Tohoku University as an Associate Professor and promoted to Professor in 2002. He received Inoue Research Award for Young Scientists 1991, the Chemical Society of Japan Award for Creative Work for 2005, and SSOCJ Daiichi-Sankyo Award for Medicinal Organic Chemistry 2013.
|Activities in Academic Societies||
The Chemical Society of Japan; American Chemical Society; Japan Society for Bioscience, Biotechnology, and Agrochemistry; the Society of Synthetic Organic Chemistry, Japan
Chemistry C (Faculty of Agriculture 1st year), Chemistry of Bioactive Compounds (Faculty of Agriculture 3rd year), Advanced Lecture on Biostructural Chemistry, Advanced Lecture on Biomolecular Sciences (gradate school)
Currents research programs in our group include: design and synthesis of molecular probes based on a simplified analogue of gambierol to identify the binding site on the voltage-gated potassium channels; total synthesis of goniodomin A, an actin-targeting polyether macrolide; total synthesis of amphidinolide N, an extremely potent cytotoxic macrolide; and total synthesis and stereochemical assignment of amphirionin-5, which exhibits cell proliferation-promoting activity.