Molecular and Chemical Life Science :
Genome Informatics


Visiting Professor NAGASE Takahiro
Campus Kazusa DNA campus
Laboratory Omics and Imformatics
Tel +81-438-52-3932
E-mail nagase@kazusa.or.jp
Website http://www.kazusa.or.jp/
Google Scholar Citations


I make full use of my experience and know-how accumulated through many years of structural and functional analysis of human genes in the exploration of genes for useful enzymes from microorganisms.


Doctor of Pharmacology, Graduate School of Pharmacology, Tokyo University of Science
Researcher, International Frontier System Research Systems, RIKEN (April 1988 to September 1989)
Special Researcher, Basic Sciences, RIKEN (October 1989 to September 1992)
Visiting Professor, Toho University (July 2005 to present)
Kazusa DNA Research Institute (October 1992 to present)

Selected Publications
  1. Stasevich TJ, Hayashi-Takanaka Y, Sato Y, Maehara K, Ohkawa Y, Sakata-Sogawa K, Tokunaga M, Nagase T, Nozaki N, McNally JG, Kimura H.: Regulation of RNA polymerase II activation by histone acetylation in single living cells. Nature, 516, 272-5 (2014)
  2. Watanabe R, Ui A, Kanno S, Ogiwara H, Nagase T, Kohno T, Yasui A.: SWI/SNF factors required for cellular resistance to DNA damage include ARID1A and ARID1B and show interdependent protein stability. Cancer Res., 74, 2465-75 (2014)
  3. Sato K, Sugiyama T, Nagase T, Kitade Y, Ueda H.: Threonine 680 phosphorylation of FLJ00018/PLEKHG2, a Rho family-specific guanine nucleotide exchange factor, by epidermal growth factor receptor signaling regulates cell morphology of Neuro-2a cells. J Biol Chem., 289, 10045-56 (2014)
  4. Sato K, Suzuki T, Yamaguchi Y, Kitade Y, Nagase T, Ueda H.: PLEKHG2/FLJ00018, a Rho family-specific guanine nucleotide exchange factor, is tyrosine phosphorylated via the EphB2/cSrc signaling pathway. Cell Signal., 26, 691-6 (2014)
  5. Daniels DL, Ford M, Schwinn MK, Benink H, Galbraith MD, Amunugama R, Jones R, Allen D, Okazaki N, Yamakawa H, Miki F, Nagase T, Espinosa JM, Urh M.: Mutual Exclusivity of MED12/MED12L, MED13/13L, and CDK8/19 Paralogs Revealed within the CDK-Mediator Kinase Module. J Proteomics Bioinform., S2-004 (2013)
  6. Kimura S, Sato K, Banno Y, Nagase T, Ueda H.: The importance of interaction with membrane lipids through the pleckstrin homology domain of the guanine nucleotide exchange factor for rho family small guanosine triphosphatase, FLJ00018. Biol Pharm Bull., 36, 1204-7 (2013)
  7. Ohata H, Miyazaki M, Otomo R, Matsushima-Hibiya Y, Otsubo C, Nagase T, Arakawa H, Yokota J, Nakagama H, Taya Y and Enari M.: NuMA is required for the selective induction of p53-target genes. Mol. Cell. Biol., 33, 2447-2457 (2013)
  8. Mori C, Yamaguchi Y, Teranishi M, Takanami T, Nagase T, Kanno S, Yasui A, Higashitani A.: Over-expression of ATR causes autophagic cell death. Genes Cells, 18, 278-287 (2013)
  9. Sato K, Handa H, Kimura M. Okano Y, Nagaoka H, Nagase T, T. Sugiyama T, Kitade Y and Ueda H.:  Identification of a Rho family specific guanine nucleotide exchange factor, FLJ00018, as a novel actin-binding protein. Cellular Signalling, 25, 41-49 (2012)
  10. Ose R, Ohara O, and Nagase T.: Galectin-1 and galectin-3 mediate protocadherin-24-dependent membrane localization of β-catenin in colon cancer cell line HCT116. Curr. Chem. Genom., 6, 18-26 (2012) 
  11. Oh-hashi K, Koga H, Nagase T, Hirata Y and Kiuchi K.: Characterization of the expression and cell-surface localization of transmembrane protein 132A. Mol. Cell. Biochem., 370, 23-33 (2012)
  12. Oshima K, Nagase T, Imai K, Nonoyama S, Obara M, Mizukami T, Nunoi H, Kanegane H, Kuribayashi F, Amemiya S, and Ohara O.: A dual reporter splicing assay using HaloTag-containing proteins. Curr. Chem. Genom., 6, 27-37 (2012)
Activities in Academic Societies

The Molecular Biology Society of Japan, Japanese Society for Chronobiology, Japanese Cancer Association, The Society for Biotechnology, Japan


Life Science

Recent Activities

Using metagenomic sequences obtained by next-generation sequencing from microotganisms in environmental samples, we attempt to find out useful enzymes by screening new genes occur in nature and apply it to industry.

Message to Students

Recent years, there is an attempt to improve microorganisms using various genome information in hopes of making a new organism factory that will produce useful substances. Let’s make nature’s unknown forces good for society.