Integrative Life Sciences :
Brain and Nervous System


Professor TANIMOTO Hiromu
Campus Katahira campus
Laboratory Neuroethology
Tel +81-22-217-6223
E-mail hiromu.tanimoto.d3@tohoku.ac.jp
Website http://www.lifesci.tohoku.ac.jp/neuroethology/
Google scholar


If you are interested in our paper and joining our lab, I encourage you to contact us.

1997 BSc: Department of Chemistry, Tokyo Metropolitan University. Supervised by Dr. H. Kaji and Prof. T. Isobe.
1999 MSc: Department of Biochemistry and Biophysics, Institute of Molecular and Cellular Biosciences, University of Tokyo. Supervised by Prof. T. Tabata.
2002 PhD: Department of Biochemistry and Biophysics, Institute of Molecular and Cellular Biosciences, University of Tokyo. Supervised by Prof. T. Tabata.
2002-2006 Postdoc: Department of Genetics and Neurobiology, University of Wuerzburg . Supervised by Prof. M. Heisenberg.
2006-2007 Group Leader of Emmy-Noether Programme (DFG) at Department of Genetics and Neurobiology, University of Wuerzburg
2008-2013 Max-Planck Research Group Leader at the Max-Planck Institute of Neurobiology
Selected Publications

Thoma V, Sakai S, Nagata K, Ishii Y, Maruyama S, Abe A, Kondo S, Kawata M, Hamada S, Deguchi R, Tanimoto H. (2023)
On the origin of appetite: GLWamide in jellyfish represents an ancestral satiety neuropeptide. Proc Natl Acad Sci U S A. 120(15):e2221493120.


Yamagata N, Imanishi Y, Wu H, Kondo S, Sano H, Tanimoto H. (2022)
Nutrient responding peptide hormone CCHa2 consolidates appetitive memory. Front. Behav. Neurosci. 16 :986064.
DOI: 10.3389/fnbeh.2022.986064


Yamagata N, Ezaki T, Takahashi T, Wu H, Tanimoto H. (2021) Presynaptic inhibition of dopamine neurons controls optimistic bias. eLife. 10:e64907.
DOI: 10.7554/eLife.64907

Ikarashi M, Tanimoto H. (2021) Drosophila acquires seconds-scale rhythmic behavior. J Exp Biol. 224(10) :jeb242443.
DOI: 10.1242/jeb.242443

Kanno M, Hiramatsu S, Kondo S, Tanimoto H, Ichinose T. (2021) Voluntary intake of psychoactive substances is regulated by the dopamine receptor Dop1R1 in Drosophila. Sci Rep. 11 :3432.
DOI: 10.1038/s41598-021-82813-0

Ichinose T, Kanno M, Wu H, Yamagata N, Sun H, Abe A, Tanimoto H. (2021) Mushroom body output differentiates memory processes and distinct memory-guided behaviors. Curr Biol. 31(6) :1294-1302.
DOI: 10.1016/j.cub.2020.12.032


Sun H, Nishioka T, Hiramatsu S, Kondo S, Amano M, Kaibuchi K, Ichinose T, Tanimoto H. (2020) Dopamine receptor Dop1R2 stabilizes appetitive olfactory memory through the Raf/MAPK pathway in Drosophila. J Neurosci. 40 (14) :2935-2942.
DOI: 10.1523/JNEUROSCI.1572-19.2020

Kondo S, Takahashi T, Yamagata N, Imanishi Y, Katow H, Hiramatsu S, Lynn K, Abe A, Kumaraswamy A, Tanimoto H. (2020)
Neurochemical organization of the Drosophila brain visualized by endogenously tagged neurotransmitter receptors. Cell Rep. 30(1) :284-297.
DOI: 10.1016/j.celrep.2019.12.018


Katow H, Takahashi T, Saito K, Tanimoto H, Kondo S. (2019)
Tango knock-ins visualize endogenous activity of G protein-coupled receptors in Drosophila. J Neurogenet. 33(2) :44-51.
DOI: 10.1080/01677063.2019.1611806

Onodera Y, Ichikawa R, Terao K, Tanimoto H, Yamagata N. (2019)
Courtship behavior induced by appetitive olfactory memory. J Neurogenet. 33(2) :143-151.
DOI: 10.1080/01677063.2019.1593978

Okuno T, Hashimoto K, Tanimoto H. (2019)
Quantification of Aggregation and Associated Brain Areas in Drosophila Melanogaster. IEEE Int Conf on Pervasive Comp & Commun Workshops (PerCom 2019). 759-764.
DOI: 10.1109/PERCOMW.2019.8730594


Ichinose T, Tanimoto H, Yamagata N. (2017) Behavioral modulation by spontaneous activity of dopamine neurons. Frontiers Syst Neurosci. 11:88.
DOI: 10.3389/fnsys.2017.00088

Thoma V, Kobayashi K, Tanimoto H. (2017) The role of the gustatory system in the coordination of feeding. eNeuro 4(6): ENEURO.0324-17.2017.
DOI: 10.1523/ENEURO.0324-17.2017


Yamagata N, Hiroi M, Kondo S, Abe A, Tanimoto H. (2016) Suppression of Dopamine Neurons Mediates Reward. PLoS Biol 14(12):e1002586.
DOI: 10.1371/journal.pbio.1002586

Ichinose T, Tanimoto H. (2016) Dynamics of memory-guided choice behavior in Drosophila. Proc Jpn Acad Ser B Phys Biol Sci; 92(8):346-357.
DOI: 10.2183/pjab.92.346

Thoma V, Knapek S, Arai S, Hartl M, Kohsaka H, Sirigrivatanawong P, Abe A, Hashimoto K, Tanimoto H. (2016) Functional dissociation in sweet taste receptor neurons between and within taste organs of Drosophila. Nat Commun 7:10678. DOI: 10.1038/ncomms10678.


Ichinose T, Aso Y, Yamagata N, Abe A, Rubin GM, Tanimoto H. (2015) Reward signal in a recurrent circuit drives appetitive long-term memory formation. Elife 4:e10719. DOI: http://dx.doi.org/10.7554/eLife.10719

Vogt K, Yarali A, Tanimoto H. (2015) Reversing stimulus timing in visual conditioning leads to memories with opposite valence in Drosophia. PLoS One, 10(10):e0139797. DOI: 10.1371/journal.pone.0139797.

Yamagata N, Ichinose T, Aso Y, Plaçais PY, Friedrich AB, Sima R, Preat T, Rubin GM, Tanimoto H. Distinct dopamine neurons mediate reward signals for short- and long-term memories. Proc Natl Acad Sci U S A. 2015. 112(2): 578-83.


Aso Y, Sitaraman D, Ichinose T, Kaun K, Vogt K, Belliart-Guérin G, Plaçais PY, Robie A, Yamagata N, Schnaitmann C, Rowell W, Johnston R, Ngo T, Chen N, Korff W, Nitabach M, Heberlein U, Preat T, Branson K, Tanimoto H, Rubin G. (2014) Mushroom body output neurons encode valence and guide memory-based action selection in DrosophilaeLife 3:e04580. 

Aso Y, Hattori D, Yu Y, Johnston R, Iyer N, Ngo T, Dionne H, Abbott L, Axel R, Tanimoto H, Rubin G. (2014) The neuronal architecture of the mushroom body provides a logic for associative learning. eLife 3:e04577. 

Vogt K, Schnaitmann C, Dylla K, Knapek S, Aso Y, Rubin GM, Tanimoto H (2014).Shared mushroom body circuits operate visual and olfactory memories in DrosophilaeLife 3:e02395
DOI: http://dx.doi.org/10.7554/eLife  

Galili DS, Dylla KV,  Lüdke A, Friedrich AB,  Yamagata  N, Wong JY, Ho CH, Szyszka P, Tanimoto H. (2014).Converging circuits for temperature and shock mediate aversive olfactory conditioning in Drosophila. Curr Biol 24: 1712-22 


Schnaitmann C, Garbers C, Wachtler T, Tanimoto H. (2013) Color discrimination with broadband photoreceotors. Curr Biol 23:2375-82 

Plaçais PY, Trannoy S, Friedrich AB, Tanimoto H, Preat T. (2013)Two pairs of mushroom body efferent neurons are required for appetitive long-term memory retrieval in Drosophila. Cell Rep 5:769-80 

Knapek S, Kahsai L, Winther AM, Tanimoto H, Nässel DR (2013). Short neuropeptide F acts as a functional neuromodulator for olfactory memory in Kenyon cells of Drosophila mushroom bodies. J Neurosci 33: 5340-5.35 

Gruber F, Knapek S, Fujita M, Matsuo K, Bräcker L, Shinzato N, Siwanowicz I, Tanimura T, Tanimoto H (2013). Suppression of conditioned odor approach by feeding is independent of taste and nutritional values in Drosophila. Curr Biol 23: 507-14


Liu C, Placais PY, Yamagata N, Pfeiffer BD, Aso Y, Friedrich AB, Siwanowicz I, Rubin GM, Preat T, Tanimoto H (2012). A subset of dopamine neurons signals reward for odour memory in Drosophila. Nature 488: 512-6 

Aso Y, Herb A, Ogueta M, Siwanowicz I, Friedrich AB, Templier T, Ito K, Scholz H, Tanimoto H (2012). Three dopamine pathways induce aversive odor memories with different stability. PLoS Genetics 8:e1002768 

Plaçais PY, Trannoy S, Isabel G, Aso Y, Siwanowicz I, Belliart-Guérin G, Vernier P, Birman S, Tanimoto H, Preat T (2012). Slow oscillations in two pairs of dopaminergic neurons gate long-term memory formation in Drosophila. Nature Neurosci 15: 592-9 

Butcher NJ, Friedrich AB, Lu Z, Tanimoto H, Meinertzhagen IA (2012). Different classes of input and output neurons reveal new features in microglomeruli of the adult Drosophilamushroom body calyx. J Comp Neurol 520: 2185-201 


Séjourné J, Plaçais PY, Aso Y, Siwanowicz I, Trannoy S, Thoma V, Tedjakumala SR, Rubin GM, Tchénio P, Ito K, Isabel G, Tanimoto H, Préat T (2011). Mushroom Body Efferent Neurons Responsible For  Aversive Olfactory Memory Retrieval In Drosophila. Nature Neurosci 14: 903-10 http://www.nature.com/neuro/journal/v14/n7/abs/nn.2846.html

Galili DS, Lüdke A, Galizia CG, Szyszka P, Tanimoto H (2011). Olfactory trace conditioning in Drosophila. J Neurosci 31: 7240-7248 

Michels B, Chen YC, Saumweber T, Mishra D, Tanimoto H, Schmid B, Engman O, Gerber B (2011). Cellular Site and Molecular Mode of Synapsin Action in Associative Learning. Learn Mem 18: 332-44 

Knapek S, Sigrist SJ, Tanimoto H (2011). Bruchpilot, a synaptic active zone protein for anesthesia-resistant memory. J Neurosci 31: 3453-3458


Aso Y, Siwanowicz I, Bräcker L, Ito K, Kitamoto T, Tanimoto H (2010). Specific Dopaminergic Neurons for the Formation of Labile Aversive Memory. Curr Biol 20: 1445-1451 

Schnaitmann C, Vogt K, Triphan T, Tanimoto H (2010). Appetitive and aversive visual learning in freely moving Drosophila.Front Behav Neurosci 4: 10 

Busch S, Tanimoto H (2010). Cellular  configuration of single octopamine neurons in Drosophila. J Comp Neurol 518: 2355-2364 

Knapek S, Gerber B, Tanimoto H (2010). Synapsin is selectively required for anesthesia-sensitive memory. Learn Mem 17: 76-79 


Busch S, Selcho M, Ito K, Tanimoto H (2009). A map of octopaminergic neurons in the Drosophila brain. J Comp Neurol 513: 643-667 

Aso Y, Grübel K, Busch S, Friedrich AB, Siwanowicz I, Tanimoto H (2009). The mushroom body of adult Drosophila characterized by GAL4 drivers. J Neurogenet 23: 156-172 


Yarali A, Niewalda T, Chen Y C, Tanimoto H, Duerrnagel S, Gerber B (2008). Pain relief learning in fruit flies. Anim Behav 76(4): 1173-1185 

Tanaka NK, Tanimoto H, Ito K (2008) Neuronal assemblies of the Drosophila mushroom body. J Comp Neurol 508: 711-755 


Thum AS, Jenett A, Ito K, Heisenberg M, Tanimoto H (2007). Multiple memory traces for olfactory reward learning inDrosophila. J Neurosci 27: 11132-11138 

Suh GS, Ben-Tabou de Leon S, Tanimoto H, Fiala A, Benzer S, Anderson DJ (2007). Light activation of an innate olfactory avoidance response in Drosophila. Current Biol 17: 905-908 


General Integrative Life Sciences, Advanced Integrative Life Science I (Brain and Nervous System)

Recent Activities

Refer to the papers listed above for details of our recent progress.

Message to Students

Inquiries and applications for positions at all levels (e.g. internship, part-time lab managers/technicians, graduate students, and postdocs) are welcome at any time.  As we are always exploring diverse research directions, your background does not necessarily match our research focus.  Availability of financial support is however not always guaranteed; you are encouraged to seek your own funding.