Molecular and Chemical Life Science :
Molecular and Network Genomics


Assistant Professor DAIGAKU Yasukazu (C)
Campus Katahira campus
Laboratory Molecular Genetics and Physiology
Tel +81-22-217-5745
E-mail daigaku@tohoku.ac.jp
Website https://www.fris.tohoku.ac.jp/researcher/advanced/daigaku.html
2001 B.S., Faculty of Science, Tohoku University
2006 Ph.D., Graduate School of life sciences,
Tohoku University
2006-2009 Research fellow, Cancer Research UK London
Research Institute
2009-2015 Research fellow, Genome Damage and Stability
Centre, University of Sussex, UK
2015- Assistant Professor, Frontier Research Institute
for interdisciplinary sciences, Tohoku University
(also appointed as the assistant professor in
graduate school of life sciences)
2015- Visiting research fellow, Genome Damage and
Stability Centre, University of Sussex, UK
Selected Publications

Y. Nakazawa, Y. Hara, Y. Oka, O.Komine, D. Heuvel#, C.Guo, Y. Daigaku, M. Isono, Y. He, M. Shimada, K. Kato, N. Jia, S. Hashimoto, Y. Kotani, Y. Miyoshi, M. Tanaka, A. Sobue, No. Mitsutake, T. Suganami, A. Masuda, K. Ohno, S. Nakada, T. Mashimo, K. Yamanaka, M.S. Luijsterburg, Tomoo Ogi, Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair. Cell, 1228-1244, 180, 2020

Z. Shao, S. Niwa, A. Higashitani, Y. Daigaku*, Vital roles of PCNA K165 modification during C. elegans gametogenesis and embryogenesis. DNA Repair, 82, 102688, 2019

N. García-Rodríguez, M. Morawska, R. P. Wong, Y. Daigaku, H. D. Ulrich, Spatial separation between replisome- and template- induced replication stress signalling, EMBO J. 3, e98369, 2018

 Y. Daigaku*, T.J. Etheridge, Y. Nakazawa, M. Nakayama, A.T. Watson, I. Miyabe, T. Ogi, M.A. Osborne, A.M. Carr*. PCNA ubiquitylation ensures timely completion of unperturbed DNA replication in fission yeast. PLoS Genet 13(5): e1006789, 2017

Y. Daigaku, A. Keszthelyi, C. A. Müller I. Miyabe, T. Brooks, R. Retkute, M. Hubank, C. A. Nieduszyski, A. M. Carr, A  global profile of replicative polymerase usage, Nat. Struct. Mol. Biol. 22, 192–8, 2015

I. Miyabe, K. Mizuno, A. Keszthelyi, Y. Daigaku, M. Skouteri, S. Mohebi, T. A. Kunkel, J. M. Murray, A. M. Carr, Polymerase δ replicates both strands after homologous recombination-dependent fork restart, Nat. Struct. Mol. Biol. 22, 932-938, 2015

Y. Daigaku, A. A. Davies and H. D. Ulrich, Ubiquitin-dependent DNA damage bypass is separable from genome replication. Nature. 465, 951-955, 2010

A. Davies, D. Huttner, Y. Daigaku, S. Chen and H. D. Ulrich, Activation of ubiquitin-dependent DNA damage bypass is mediated by replication protein A. Mol Cell. 29, 625-636, 2008

Y. Daigaku, Roadworks of DNA Damage Bypass during and after Replication, Genes and Environment. 34, 77-88, 2012 (review article)

Activities in Academic Societies

Genetic Society of Japan

Recent Activities

During each cell division, genomic information must be efficiently replicated and subsequently segregated at mitosis. However, the process of replication is not without incident - it is well established that the replication machinery encounters various obstacles and is designed to have a degree of flexibility, allowing cells to tolerate the problem within limited time during S phase. By combining genome-wide analysis of DNA replication with biochemical analysis, my research aim to elucidate the dynamic process underling DNA replication and its influence to integrity of genome information.

Message to Students

Science is vital in the world!