I studied on molecular mechanisms of oncogenesis and malignancy. I also studied on anticancer effects of molecular targeted drugs and resistance to chemotherapy in several malignant neoplasms including pancreatic, colorectal, breast and lung cancers. Now, I am interested in regulatory mechanisms of cell division because disruption of the regulation will result in the chromosomal instability and, ultimately, cancer.
|Activities in Academic Societies||
The Japanese Society of Internal Medicine, Japanese Cancer Association, Japan Society of Clinical Oncology, Japanese Society of Medical Oncology
Cancer is a result of accumulated genomic aberration. In addition to alteration in DNA sequence and epigenetic modification, abnormalities of chromosome number and structure are also related with oncogenesis. I have studied on regulatory mechanisms of centrosome, which is essential organelle in accurate cell division. It also interest me how cancer with chromosomal instability survive elimination machinery of many checkpoints. Finally, I aim for development of a new class of chemotherapeutic drugs which targets the cell division machinery.