GO TOP

Field

Molecular and Chemical Life Science :
Multilevel Biomolecular Structure and Dynamics

Research

JAPANESE
Professor MIZUKAMI Shin
Campus Katahira campus
Laboratory Biofunctional Chemistry and Nanobiotechnology
Tel +81-22-217-5116
E-mail shin.mizukami.a6＠tohoku.ac.jp
Website https://www2.tagen.tohoku.ac.jp/lab/mizukami/

I was born in Tokyo, and grew up in Kanto region. After studying in US (California), I returned to Kansai region in Japan and started my academic career. Since I was fascinated by the interest and beauty of “chemistry”, especially “organic chemistry”, I investigated with the motivation to understand life by using original chemical approaches. As my ultimate objective, I hope to our bioanalytical tools to develop novel drugs or medical technologies.

Career
1997 Univ of Tokyo: B.S.
2002 Univ of Tokyo: Ph.D. (Development of fluorescent seosors for anions that works in aqueous solution; Thesis advisor: Prof. Tetsuo Nagano).
2002-2004 National Institute of Advanced Industrial Science and Technology (AIST): AIST Postdoctoral Fellow
2002-2005
Stanford Univ, Dept of Chemistry: JSPS Postdoctoral Fellow for Research Abroad
2005-2009
Osaka Univ, Grad School of Engineering: Assistant Professor
2009-2016 Osaka Univ, Grad School of Engineering: Associate Professor
2009-2016 Osaka Univ, Immunology Frontier Research Center (IFReC): Associate Professor
2016-present Tohoku University, Institute of Multidisciplinary Research for Advanced Materials (IMRAM):  Professor
Selected Publications
  1. Enzyme-Triggered Compound Release using Functionalized Antimicrobial Peptide Derivatives
    S. Mizukami, M. Kashibe, K. Matsumoto, Y. Hori, K. Kikuchi
    Chem. Sci.  2017, 8, 3047–3053.
  2. Real-Time Intravital Imaging of pH Variation Associated with Osteoclast Activity
    H. Maeda, T. Kowada, J. Kikuta, M. Furuya, M. Shirazaki, S. Mizukami, M. Ishii, K. Kikuchi
    Nat. Chem. Biol.  2016, 12, 579–585.
  3. An Enzyme-Responsive Metal-Enhanced Near-Infrared Fluorescence Sensor Based on Functionalized Gold Nanoparticles
    Z. Zeng, S. Mizukami, K. Fujita, K. Kikuchi
    Chem. Sci.  2015, 6, 4934–4939.
  4. Activatable 19F MRI Nanoparticle Probes for the Detection of Reducing Environments
    T. Nakamura, H. Matsushita, F. Sugihara, Y. Yoshioka, S. Mizukami, K. Kikuchi
    Angew. Chem. Int. Ed.  2015, 54, 1007–1010.
  5. Multifunctional Core-shell Silica Nanoparticles for Highly Sensitive 19F Magnetic Resonance Imaging
    H. Matsushita, S. Mizukami, F. Sugihara, Y. Nakanishi, Y. Yoshioka, K. Kikuchi
    Angew. Chem. Int. Ed.  2014, 53, 1008–1011.
  6. Small-Molecule Based Protein-Labeling Technology in Live Cell Studies: Probe-Design Concepts and Applications
    S. Mizukami, Y. Hori, K. Kikuchi
    Acc. Chem. Res.  2014, 47, 247–256.
  7. No-Wash Protein Labeling with Designed Fluorogenic Probes and Application to Real-Time Pulse-Chase Analysis
    S. Mizukami, S. Watanabe, Y. Akimoto, K. Kikuchi
    J. Am. Chem. Soc.  2012, 134, 1623–1629.
  8. Covalent Protein Labeling with a Lanthanide Complex and its Application to Photoluminescence Lifetime-Based Multicolor Bioimaging
    S. Mizukami, T. Yamamoto, A. Yoshimura, S. Watanabe, K. Kikuchi
    Angew. Chem. Int. Ed.  2011, 50, 8750–8752.
  9. Photocontrolled Compound Release System Using Caged Antimicrobial Peptide
    S. Mizukami, M. Hosoda, T. Satake, S. Okada, Y. Hori, T. Furuta, K. Kikuchi
    J. Am. Chem. Soc. 2010, 132, 9524–9525.
Activities in Academic Societies

Chemical Society of Japan, Pharmaceutical Society of Japan, Japanese Society for Chemical Biology, Japanese Society for Molecular Imaging, American Chemical Society
Teaching

Advanced Lecture on Biomolecular Sciences, Advanced Biochemistry, Advanced Lecture on Biofunctional Chemistry III

Recent Activities

When we want to investigate something, we first observe it, then touch and handle it. If we use light and adequate photoresponsive functional molecules, even intracellular biomolecule can be noninvasively observed and manipulated. For such studies, we are developing functional compouonds such as fluorescent probes or photoresponsive peptide tools.

Message to Students

Chemistry can produce new materials with various functions. If you want to depict your idea in designing new molecules, to observe the behaviors of invisible biomolecules, to regulate biomolecular or cellular functions with molecules and light, or to study both life science and chemistry, or if you have any interest in our research, please feel free to contact us!

Research