GO TOP

Field

Ecological Developmental Adaptability Life Sciences :
Biological Dynamics

Research

Assistant Professor NAKAJIMA Yuichiro (C)
Campus Aobayama campus
Laboratory Histogenetic Dynamics
Tel +81-22-795-6701
E-mail yuichiro.nakajima.d2@tohoku.ac.jp
Website http://www.fris.tohoku.ac.jp/researcher/creative/nakajima.html https://twitter.com/nyuichiro97 https://scholar.google.co.jp/citations?user=AYdMFUgAAAAJ&hl=ja https://researchmap.jp/7000020936/
  My research career began as a student in The University of Tokyo, and I conducted a postdoc research at the Stowers Institute for Medical Research in Kansas City, USA. Since April 2016, I started my own group in Tohoku University as a faculty member of the Frontier Research Institute for Interdisciplinary Sciences. I have been studying mechanisms of tissue homeostasis, diseases and environmental responses, using fruit fly and small jellyfish. I particularly focus on dissecting cellular behaviors in living organisms by intensive observations with manipulations.
Career
2006  B.S. The University of Tokyo, Japan
2008  M.S. Graduate School of Pharmaceutical sciences, The University of Tokyo, Japan (Advisor: Dr. Masayuki Miura)
(2008-2011 Research Fellowships for Young Scientists, JSPS, DC1)
2011  Ph.D. Graduate School of Pharmaceutical sciences, The University of Tokyo, Japan (Advisor: Dr. Masayuki Miura)
2011-2016  Postdoctoral research associate, Stowers Institute for Medical Research, Kansas City, MO, USA (Advisor: Dr. Matt Gibson)
(2014-2016  Postdoctoral Fellowship for Research Abroad, JSPS)
2016-present  Assistant Professor, Frontier Research Institute for Interdisciplinary Sciences, Tohoku University (Graduate School of Life Sciences, Tohoku University)
Selected Publications
  1. Fujita S, Kuranaga E, and *Nakajima Y. “Cell proliferation controls body size growth, tentacle morphogenesis, and regeneration in hydrozoan jellyfish Cladonema pacificumPeerJ. 7: e7579, 2019.
  2. *Nakajima Y, Lee ZT, McKinney SA, Swanson SK, Florens L, Gibson MC. “Junctional tumor suppressors interact with 14-3-3 proteins to control planar spindle alignment” Journal of Cell Biology. 218(6):1824-1838, 2019.
  3. *Nakajima Y. “Mitotic spindle orientation in epithelial homeostasis and plasticity” The Journal of Biochemistry, 164(4): 277-284, 2018.
  4. *Nakajima Y, and Kuranaga E. “Caspase-dependent non-apoptotic processes in development” Cell Death & Differentiation, 24(8): 1422-1430, 2017.
  5. Kawamoto Y, Nakajima Y, and Kuranaga E. “Apoptosis in Cellular Society: Communication between Apoptotic Cells and Their Neighbors” International Journal of Molecular Sciences, 17(12), pii: E2144, 2016.
  6. Nakajima Y, and Gibson MC. “Developmental Patterning: Putting the Squeeze on Mis-specified Cells” Current Biology, 26 (5): R204-206, 2016.
  7. Nakajima Y, and Gibson MC. “Epithelial cell division: aurora kicks lgl to the cytoplasmic curb” Current Biology, 25 (1): R43-45, 2015.
  8. Yamaguchi Y., Kuranaga E., Nakajima Y., Koto A., Takemoto K., and Miura M. “In vivo monitoring of caspase activation using a fluorescence resonance energy transfer-based fluorescent probe” Methods in Enzymology, 544: 299-325, 2014.
  9. Nakajima Y., Meyer EJ., Kroesen A., McKinney SA. and Gibson MC. “Epithelial junctions maintain tissue architecture by directing planar spindle orientation”  Nature, 500 (7462): 359-62, 2013. Highlighted by Nicola McCarthy, “In the plane.” Nature Reviews Cancer, 13, 606–607 (2013). Recommended by Faculty of 1000. 
  10. Nakajima Y., Kuranaga E., Sugimura K., Miyawaki A. and Miura M. Nonautonomous Apoptosis is Triggered by Local Cell Cycle Progression during Epithelial Replacement in Drosophila” Molecular and Cellular Biology, 31(12): 2499-2512, 2011.  Recommended by Faculty of 1000.
Activities in Academic Societies
The Molecular Biology Society of Japan, Japanese Society of Developmental Biologists, Genetics Society of America
Teaching
Molecular and Cellular Biology, General Education Seminar

Recent Activities

Our group is currently using both fruit fly and jellyfish and is trying to elucidate the molecular and cellular machinery underlying tissue homeostasis, diseases and seasonal responses. The overlapping objectives of my aims address a fundamental question: how animals, including humans, respond to distinct perturbations such as stress, injury and environmental changes.

Message to Students

From the beginning of my scientific career, I had been passionate about understanding cellular behaviors in “cellular societies” such as tissues and organs. You may realize how beautiful to see such a small world with microscope and how fascinating to address questions with your ideas and conduct experiments. Please let us know if you are interested in our research.