Integrative Life Sciences :
Cellular Network


Assistant Professor TSUNEMATSU Tomomi
Campus Katahira campus
Laboratory Super-Network Brain Physiology
Tel +81-22-795-4751
E-mail tsune@tohoku.ac.jp
Website https://www2.fris.tohoku.ac.jp/~tsunematsu/
 I am interested in sleep research because I love sleep. I have a fascinating dream during night. In addition, I make every effort to elucidate mechanism and function of sleep during day.
2006              B.S. College of Biological Sciences, Second Cluster of Colleges, University of Tsukuba
2009-2011     JSPS Research Fellowship (DC2)
2011              Ph.D. Department of Physiological Sciences, School of Life Science, The Graduate University for Advanced Studies
2011-2014     JSPS Postdoctoral Fellow, National Institute for Physiological Sciences and Nagoya University
2014-2016     JSPS Postdoctoral Fellow for Research Abroad, University of Strathclyde
2016-2017     Research Associate, University of Strathclyde
2017-              Assistant Professor, Tohoku University
Selected Publications
  1. Scharf R, Tsunematsu T, McAlinden N, Dawson MD, Sakata S, Mathieson K (2016) Depth-specific optogenetics control in vivo with a scalable, high-density µLED neural probe. Sci Rep 6: Article number: 28381
  2. Tsunematsu T, Ueno T, Tabuchi S, Inutsuka A, Tanaka KF, Hasuwa H, Kilduff TS, Terao A, Yamanaka A (2014) Optogenetic manipulation of activity and temporally-controlled cell-specific ablation reveal a role for MCH neurons in sleep/wake regulation. J Neurosci 34(20): 6896-6909.
  3. Tsunematsu T, Tabuchi S, Tanaka KF, Boyden ES, Tominaga M, Yamanaka A (2013) Long-lasting silencing of orexin/hypocretin neurons using archaerhodopsin induces slow-wave sleep in mice. Behavioural Brain Research 255: 64-74.
  4. Tsunematsu T, Kilduff TS, Boyden ES, Takahashi S, Tominaga M, Yamanaka A (2011) Acute optogenetic silencing of orexin/hypocretin neurons induces slow-wave sleep in mice. J Neurosci 31: 10529-10539. Selected as must read paper in F1000 [score 8.0]
  5. Tsunematsu T, Fu LY, Yamanaka A, Ichiki K, Tanoue A, Sakurai T, van den Pol AN (2008) Vasopressin increases locomotion through a V1a receptor in orexin/hypocretin neurons: implications for water homeostasis. J Neurosci 28:228-238.
Activities in Academic Societies
Japanese Society of Sleep Research, The Japan Neuroscience Society, Physiological Society of Japan, The Japanese Pharmacological Society, Society for Neuroscience

Recent Activities

  Sleep is one of the instinctive behavior. Mammals have two stages of sleep, i.e., rapid eye movement (REM) sleep and non-REM sleep, which show completely different brain activities. Although no one can live without sleep, physiological function of sleep is one of the mystery-shrouded issue in the field of brain science so far. To investigate this, I have started to elucidate the regulatory mechanism of sleep/wakefulness using mice.
  First, I introduced optogenetics technique to identify the neural network which regulates sleep/wakefulness. Optogenetics enables us to manipulate specific type of neural activity at high temporal resolution. Using this, I have revealed that inhibition of orexin neural activities in lateral hypothalamus induces the transition from wakefulness to non-REM sleep. In addition, activation of melanin-concentrating hormone neural activities can cause transition from non-REM sleep to REM sleep (Tsunematsu et al., J Neurosci 2011 and 2014).
  Next, I recorded multiple neural activities from pons, cortex and hippocampus using silicon probe with 32 channels in unanesthetized mice. I focused on information processing during non-REM sleep and REM sleep, especially the relationship firing pattern and synchronization of neural activities.
  With various experimental techniques, I have learnt and knowledge I have gained in the past, I am excited to further explore, and thus unravel the mystery of sleep.

Message to Students

  Please feel free to contact me if you are interested in sleep research. Let’s discuss what we can do together!