I am interested in sleep research because I love sleep. I have a fascinating dream during night. In addition, I make every effort to elucidate mechanism and function of sleep during day.
Assistant Professor TSUNEMATSU Tomomi
Super-Network Brain Physiology
2006 B.S. College of Biological Sciences, Second Cluster of Colleges, University of Tsukuba
2009-2011 JSPS Research Fellowship (DC2)
2011 Ph.D. Department of Physiological Sciences, School of Life Science, The Graduate University for Advanced Studies
2011-2014 JSPS Postdoctoral Fellow, National Institute for Physiological Sciences and Nagoya University
2014-2016 JSPS Postdoctoral Fellow for Research Abroad, University of Strathclyde
2016-2017 Research Associate, University of Strathclyde
2017- Assistant Professor, Tohoku University
|Activities in Academic Societies||
Japanese Society of Sleep Research, The Japan Neuroscience Society, Physiological Society of Japan, The Japanese Pharmacological Society, Society for Neuroscience
Sleep is one of the instinctive behavior. Mammals have two stages of sleep, i.e., rapid eye movement (REM) sleep and non-REM sleep, which show completely different brain activities. Although no one can live without sleep, physiological function of sleep is one of the mystery-shrouded issue in the field of brain science so far. To investigate this, I have started to elucidate the regulatory mechanism of sleep/wakefulness using mice.
First, I introduced optogenetics technique to identify the neural network which regulates sleep/wakefulness. Optogenetics enables us to manipulate specific type of neural activity at high temporal resolution. Using this, I have revealed that inhibition of orexin neural activities in lateral hypothalamus induces the transition from wakefulness to non-REM sleep. In addition, activation of melanin-concentrating hormone neural activities can cause transition from non-REM sleep to REM sleep (Tsunematsu et al., J Neurosci 2011 and 2014).
Next, I recorded multiple neural activities from pons, cortex and hippocampus using silicon probe with 32 channels in unanesthetized mice. I focused on information processing during non-REM sleep and REM sleep, especially the relationship firing pattern and synchronization of neural activities.
With various experimental techniques, I have learnt and knowledge I have gained in the past, I am excited to further explore, and thus unravel the mystery of sleep.