Molecular and Chemical Life Science :
Microbial Evolution and Function Research


Assistant Professor SATO Yukari
Campus Katahira campus
Laboratory Microbial Evolution and Function Research
Tel +81-22-217-6227
E-mail yusato@ige.tohoku.ac.jp
Website http://www.ige.tohoku.ac.jp/bishin/index.html
Google Scholar


My hometown is Sendai Miyagi. I like taking photographs of not only protein crystals but also stars and wild-life.
2001. 3    Miyagi university of Education, Faculty of Education
2003. 3    Tohoku university, Graduate School of Life Sciences (M.S. in Life Sciences)
2007. 3    Tohoku university, Graduate School of Life Sciences (Ph.D. in Life Sciences)
2007. 4    Postdoctoral fellow, National Institute for Agro-Environmental Sciences
2008. 4    Postdoctoral fellow, Japan biological informatics consortium
2013. 3    Postdoctoral fellow, High Energy Accelerator research Organization
2017. 4-   Assistant professor, Tohoku University, Graduate School of Life Sciences
Selected Publications
  1. Ray-Gallet D*, Ricketts MD*, Sato Y*, Gupta K, Boyarchuk E, Senda T, Marmorstein R, and Almouzni G. Functional activity of the H3.3 histone chaperone complex HIRA requires trimerization of the HIRA subunit. Nature Commun. 9, 3013 (2018) *Equal contribution
  2. Katsuyama Y*, Sato Y*, Sugai Y, Higashiyama Y, Senda M, Senda T, and Ohnishi Y. Crystal structure of the nitrosuccinate lyase CreD in complex with fumarate provides insights into the catalytic mechanism for nitrous acid elimination. FEBS J. 285, 1540-1555 (2018) *Equal contribution
  3. Prokop Z*, Sato Y*, Brezovsky J*, Mozga T, Chaloupkova R, Koudelakova T, Jerabek P, Stepankova V, Natsume R, van Leeuwen JG, Janssen DB, Florian J, Nagata Y, Senda T, and Damborsky J. Enantioselectivity of haloalkane dehalogenases and its modulation by surface loop engineering. Angew. Chem. 49, 611-615 (2010) *Equal contribution
  4. Sato Y, Natsume R, Tsuda M, Nagata Y, and Senda T. Crystallization and preliminary crystallographic analysis of haloalkane dehalogenase DbjA from Bradyrhizobium japonicum USDA110. Acta Crystallogr. F63, 294-296 (2007)
  5. Sato Y, Monincova M, Chaloupkova R, Prokop Z, Ohtsubo Y, Minamisawa K, Tsuda M, Damborsky J, and Nagata Y. Two Rhizobial Strains, Mesorhizobium loti MAFF303099 and Bradyrhizobium japonicum USDA110, encode haloalkane dehalogenases with Novel Structures and Substrate specificities. Appl. Environ. Micro. 11, 1741-1766 (2006)
Activities in Academic Societies
Japan Society for Bioscience, Biotechnology and Agrochemistry, The Japanese Biochemical Society, Protein Science Society of Japan

Recent Activities

I am studying the molecular basis of (1) transcription-associated proteins in human and (2) biocatalyst enzymes from bacteria, using X-ray crystal structure analysis. In these studies, I faced a problem with the disordered regions in the proteins. The disordered region is in general important in interaction with small molecules or other proteins, but it can also cause degradation or precipitation of proteins. I am seeking the way to efficiently analyze the function of the disordered region.

Message to Students

It is fun to find a connection between life phenomenon and protein structure. Since Sendai is a small city, you can easily reach the destination and urban area. I am sure that you can enjoy your life here.