Integrative Life Sciences :
Cooperative faculties


Professor OSUMI Noriko
Campus Seiryo campus
Laboratory Developmental Neuroscience
Tel +81-22-717-8203
E-mail osumi@med.tohoku.ac.jp
Website http://www.dev-neurobio.med.tohoku.ac.jp/member/staff/osumi/index.html
1979-1985 School of Dentistry, Tokyo Medical & Dental University
1985-1989 Graduate School of Dentistry, Tokyo Medical & Dental University
1989-1996 Research Associate, Department of Craniofacial Morphogenesis and Anomalies, Tokyo Medical & Dental University
1996-1998 Associate Professor, National Institute of Neuroscience, National Center of Neurology & Psychiatry
1998- Present position
2006- Special Advisor for Gender Equality (Tohoku University)
2008-2010 Distinguished Professor (Tohoku University)
2018 Vice President (Tohoku University)
Selected Publications
  1. The Autism-Related Protein SETD5 Controls Neural Cell Proliferation through Epigenetic Regulation of rDNA Expression. Nakagawa T, Hattori S, Nobuta R, Kimura R, Nakagawa M, Matsumoto M, Nagasawa Y, Funayama R, Miyakawa T, Inada T, Osumi N, Nakayama KI, Nakayama K. iScience. 2020 Apr 6;23(4):101030. doi: 10.1016/j.isci.2020.101030. Online ahead of print. PMID: 32299058
  2. Comprehensive histochemical profiles of histone modification in male germline cells during meiosis and spermiogenesis: Comparison of young and aged testes in mice. Tatehana M, Kimura R, Mochizuki K, Inada H, Osumi N. PLoS One. 2020 Apr 8;15(4):e0230930. doi: 10.1371/journal.pone.0230930. eCollection 2020. PMID: 32267870
  3. Dmrt genes participate in the development of Cajal-Retzius cells derived from the cortical hem in the telencephalon. Kikkawa T, Sakayori N, Yuuki H, Katsuyama Y, Matsuzaki F, Konno D, Abe T, Kiyonari H, Osumi N. Dev Dyn. 2020 Jun;249(6):698-710. doi: 10.1002/dvdy.156. Epub 2020 Feb 12. PMID: 32012381
  4. Effects of enriched endogenous omega-3 fatty acids on age-related hearing loss in mice. Honkura Y, Suzuki J, Sakayori N, Inada H, Kawase T, Katori Y, Osumi N. BMC Res Notes. 2019 Nov 26;12(1):768. doi: 10.1186/s13104-019-4809-8. PMID: 31771637
  5. "Passenger gene" problem in transgenic C57BL/6 mice used in hearing research. Suzuki J, Inada H, Han C, Kim MJ, Kimura R, Takata Y, Honkura Y, Owada Y, Kawase T, Katori Y, Someya S, Osumi N. Neurosci Res. 2019 Oct 14:S0168-0102(19)30469-9. doi: 10.1016/j.neures.2019.10.007. Online ahead of print. PMID: 31622631
  6. Structural and functional defects of the respiratory neural system in the medulla and spinal cord of Pax6 mutant rats. Ikeda K, Onimaru H, Inada H, Tien Lin S, Arata S, Osumi N. Brain Res Bull. 2019 Oct;152:107-116. doi: 10.1016/j.brainresbull.2019.07.007. Epub 2019 Jul 10. PMID: 31301380
  7. SETDB1 is essential for mouse primordial germ cell fate determination by ensuring BMP signaling. Mochizuki K, Tando Y, Sekinaka T, Otsuka K, Hayashi Y, Kobayashi H, Kamio A, Ito-Matsuoka Y, Takehara A, Kono T, Osumi N, Matsui Y. Development. 2018 Dec 3;145(23):dev164160. doi: 10.1242/dev.164160. PMID: 30446626
  8. Repression of Somatic Genes by Selective Recruitment of HDAC3 by BLIMP1 Is Essential for Mouse Primordial Germ Cell Fate Determination. Mochizuki K, Hayashi Y, Sekinaka T, Otsuka K, Ito-Matsuoka Y, Kobayashi H, Oki S, Takehara A, Kono T, Osumi N, Matsui Y. Cell Rep. 2018 Sep 4;24(10):2682-2693.e6. doi: 10.1016/j.celrep.2018.07.108. PMID: 30184502
  9. Pax6-dependent regulation of the rat Fabp7 promoter activity. Inada H, Numayama-Tsuruta K, Mochizuki K, Sasaki-Hoshino M, Osumi N. Genes Cells. 2018 Jul 9. doi: 10.1111/gtc.12623. Online ahead of print. PMID: 29984875
  10. Risk of Neurodevelopmental Disease by Paternal Aging: A Possible Influence of Epigenetic Alteration in Sperm. Kimura R, Yoshizaki K, Osumi N. Adv Exp Med Biol. 2018;1012:75-81. doi: 10.1007/978-981-10-5526-3_8. PMID: 29956196
  11. Conserved and divergent functions of Pax6 underlie species-specific neurogenic patterns in the developing amniote brain. Yamashita W, Takahashi M, Kikkawa T, Gotoh H, Osumi N, Ono K, Nomura T. Development. 2018 Apr 16;145(8):dev159764. doi: 10.1242/dev.159764. PMID: 29661783
  12. Maekawa M, Watanabe A, Iwayama Y, Kimura T, Hamazaki K, Balan S, Ohba H, Hisano Y, Nozaki Y, Ohnishi T, Toyoshima M, Shimamoto C, Iwamoto K, Bundo M, Osumi N, Takahashi E, Takashima A, Yoshikawa T: Polyunsaturated fatty acid deficiency during neurodevelopment in mice models the prodromal state of schizophrenia through epigenetic changes in nuclear receptor genes. Transl Psychiatry. 7(9), e1229, 2017 (Press released and distributed via media)
  13. Kikkawa T, Takahashi M, Osumi N: Electroporation in the Rodent Embryonic Brain Using Whole Embryo Culture System. Current Protoc Neurosci 78, 3.30.1-3.30.16, 2017
  14. Yoshizaki K, Furuse T, Kimura R, Tucci V, Kaneda H, Wakana S, Osumi N : Paternal Aging Affects Behavior in Pax6 Mutant Mice: A Gene/Environment Interaction in Understanding Neurodevelopmental Disorders. PLoS ONE 11(11), e0166665, 2016 (Press released and distributed via media)
  15. Hiraoka K, Sumiyoshi A, Nonaka H, Kikkawa T, Kawashima R, Osumi N: Regional Volume Decreases in the Brain of Pax6 Heterozygous Mutant Rats: MRI Deformation-Based Morphometry. PLoS ONE 11(6), e0158153, 2016
  16. Nagasaki et al: Rare variant discovery by deep whole-genome sequencing of 1,070 Japanese individuals. Nat Comm, 2015 Aug 21; 6: 8018. doi: 10.1038/ncomms9018  (Press released and distributed via media)
  17. Matsumata M, Sakayori N, Maekawa M, Owada Y, Yoshikawa T, Osumi N: The effects of Fabp7 and Fabp5 on postnatal hippocampal neurogenesis in the mouse. Stem Cells 30(7), 1532-1543, 2012 (Press released and distributed via media)
  18. Tsunekawa Y, Britto JM, Takahashi M, Polleux F, Tan SS, Osumi N: Cyclin D2 in the basal process of neural progenitors is linked to non-equivalent cell fates. EMBO J 31(8), 1879-1892, 2012 (Chosen as Editor’s Choice)
  19. Umeda T, Takashima N, Nakagawa R, Maekawa M, Ikegami S, Yoshikawa T, Kobayashi K, Okanoya K, Inokuchi K, Osumi N: Evaluation of Pax6 mutant rat as a model for autism. PLoS ONE 5(12), e15500, 2010
  20. Hara Y, Nomura T, Yoshizaki K, Frisén J, Osumi N: Impaired hippocampal neurogenesis and vascular formation in ephrin-A5-deficient mice. Stem Cells 28(5), 974-983, 2010 (Press released and distributed via media)
  21. Osumi N, Shinohara H, Numayama-Tsuruta K, Maekawa M: Concise review: Pax6 transcription factor contributes to both embryonic and adult neurogenesis as a multifunctional regulator. Stem Cells 26(7), 1663-1672, 2008
  22. Matsuo T*, Osumi-Yamashita N* et al.: A mutation in Pax6-gene in Small eye rat is associated with impaired migration of midbrain crest cells. Nat Genet, 3(4), 299-304, 1993 (*equally contributed)

Activities in Academic Societies
Science Council of Japan
The Molecular Biology Society of Japan
The Japan Neuroscience Society
The Japanese Society for Neurochemistry
The Japanese Society of Neuropsychopharmacology
Japanese Society of Developmental Biologists
Japan Society for Cell Biology
Society for Neuroscience