Integrative Life Sciences :
Cooperative faculties


Professor OSUMI Noriko
Campus Seiryo campus
Laboratory Developmental Neuroscience
Tel +81-22-717-8203
E-mail noriko.osumi.c7@tohoku.ac.jp
Website http://www.dev-neurobio.med.tohoku.ac.jp/member/staff/osumi/index.html
Google Scholar
Exploring novel phenomena that you are attracted in life science
1979-1985 School of Dentistry, Tokyo Medical & Dental University
1985-1989 Graduate School of Dentistry, Tokyo Medical & Dental University
1989-1996 Research Associate, Department of Craniofacial Morphogenesis and Anomalies, Tokyo Medical & Dental University
1996-1998 Associate Professor, National Institute of Neuroscience, National Center of Neurology & Psychiatry
1998- Present position
2006-2018 Special Advisor for Gender Equality (Tohoku University)
2012- TWAS Associate Fellow (Tohoku University)
2019- EMBO Associate Member
Selected Publications
  1. Paternal age affects offspring via an epigenetic mechanism involving REST/NRSF. Yoshizaki K, Kimura R, Kobayashi H, Oki S, Kikkawa T, Mai L, Koike K, Mochizuki K, Inada H, Matsui Y, Kono T, Osumi N. EMBO Rep. 2021 Jan 5:e51524. doi: 10.15252/embr.202051524.  (Press released and distributed via media)
  2. Identification of FMRP target mRNAs in the developmental brain: FMRP might coordinate Ras/MAPK, Wnt/β-catenin, and mTOR signaling during corticogenesis. Casingal CR, Kikkawa T, Inada H, Sasaki Y, Osumi N. Mol Brain. 2020 Dec 16;13(1):167. doi: 10.1186/s13041-020-00706-1.  (Press released and distributed via media)
  3. The Autism-Related Protein SETD5 Controls Neural Cell Proliferation through Epigenetic Regulation of rDNA Expression. Nakagawa T, Hattori S, Nobuta R, Kimura R, Nakagawa M, Matsumoto M, Nagasawa Y, Funayama R, Miyakawa T, Inada T, Osumi N, Nakayama KI, Nakayama K. iScience. 2020 Apr 6;23(4):101030. doi: 10.1016/j.isci.2020.101030. Online ahead of print. PMID: 32299058
  4. Comprehensive histochemical profiles of histone modification in male germline cells during meiosis and spermiogenesis: Comparison of young and aged testes in mice. Tatehana M, Kimura R, Mochizuki K, Inada H, Osumi N. PLoS One. 2020 Apr 8;15(4):e0230930. doi: 10.1371/journal.pone.0230930. eCollection 2020. PMID: 32267870
  5. Dmrt genes participate in the development of Cajal-Retzius cells derived from the cortical hem in the telencephalon. Kikkawa T, Sakayori N, Yuuki H, Katsuyama Y, Matsuzaki F, Konno D, Abe T, Kiyonari H, Osumi N. Dev Dyn. 2020 Jun;249(6):698-710. doi: 10.1002/dvdy.156. Epub 2020 Feb 12. PMID: 32012381
  6. SETDB1 is essential for mouse primordial germ cell fate determination by ensuring BMP signaling. Mochizuki K, Tando Y, Sekinaka T, Otsuka K, Hayashi Y, Kobayashi H, Kamio A, Ito-Matsuoka Y, Takehara A, Kono T, Osumi N, Matsui Y. Development. 2018 Dec 3;145(23):dev164160. doi: 10.1242/dev.164160. PMID: 30446626
  7. Repression of Somatic Genes by Selective Recruitment of HDAC3 by BLIMP1 Is Essential for Mouse Primordial Germ Cell Fate Determination. Mochizuki K, Hayashi Y, Sekinaka T, Otsuka K, Ito-Matsuoka Y, Kobayashi H, Oki S, Takehara A, Kono T, Osumi N, Matsui Y. Cell Rep. 2018 Sep 4;24(10):2682-2693.e6. doi: 10.1016/j.celrep.2018.07.108. PMID: 30184502
  8. Nagasaki et al: Rare variant discovery by deep whole-genome sequencing of 1,070 Japanese individuals. Nat Comm, 2015 Aug 21; 6: 8018. doi: 10.1038/ncomms9018  (Press released and distributed via media)
  9. Tsunekawa Y, Britto JM, Takahashi M, Polleux F, Tan SS, Osumi N: Cyclin D2 in the basal process of neural progenitors is linked to non-equivalent cell fates. EMBO J 31(8), 1879-1892, 2012 (Chosen as Editor’s Choice)
  10. Matsuo T*, Osumi-Yamashita N* et al.: A mutation in Pax6-gene in Small eye rat is associated with impaired migration of midbrain crest cells. Nat Genet, 3(4), 299-304, 1993 (*equally contributed)

Activities in Academic Societies
Science Council of Japan, The Molecular Biology Society of Japan, The Japan Neuroscience Society, The Japanese Society for Neurochemistry, The Japanese Society of Neuropsychopharmacology, Japanese Society of Developmental Biologists, Japan Society for Cell Biology, Society for Neuroscience

Recent Activities