Molecular and Chemical Life Science :
Cooperative faculties


Professor DOI Takayuki
Campus Aobayama campus
Laboratory Bioorganic Medicinal Chemistry
Tel +81-22-795-6865
E-mail doi_taka@mail.pharm.tohoku.ac.jp
Website http://www.pharm.tohoku.ac.jp/~hannou/ http://www.pharm.tohoku.ac.jp/~hannou/index-e.html

Takayuki Doi was born in 1963 in Okayama, Japan. He received his Ph.D. in 1991 under the direction of Professor Takashi Takahashi in Tokyo Institute of Technology. After spending two and a half years at Columbia University as a postdoctoral scientist with Professor Gilbert Stork, he joined the Department of Chemical Engineering in Tokyo Tech as Assistant Professor in 1993. He was appointed Associate Professor in 2001 at Tokyo Tech and promoted to Full Professor (Heterocyclic Chemistry Group) at Graduate School of Pharmaceutical Sciences in Tohoku University in 2008. He joined Department of Molecular and Chemical Life Sciences (Bioorganic Medicinal Chemistry Group) at Graduate School of Life Sciences in Tohoku University. 
His research interest includes total synthesis of biologically active natural products, especially cyclic peptides possessing non-proteinogenic amino acids; biological evaluation and structure activity relationships of their synthetic derivatives.
He was a part of Organizing Committee of Japan Combinatorial Chemistry Focus Group (1998–2009). He has been Associate Editor of Bulletin of the Chemical Society of Japan (2011-present); Editorial Board Member of Combinatorial Chemistry & High Throughput Screening (2008-present); Editorial Advisory Board of ACS Omega (2017-present). He received the Progress Award in Synthetic Organic Chemistry, Japan (2000); and the Pharmaceutical Society of Japan Award for Divisional Scientific Promotions (2013).

Selected Publications
  1. Y. Onda, Y. Masuda, M. Yoshida, T. Doi, Conformation-based Design and Synthesis of Apratoxin A Mimetics Modified at the α,β-Unsaturated Thiazoline Moiety, J. Med. Chem. 2017, 60(15), 6751-6765.  doi:10.1021/acs.jmedchem.7b00833
  2. Y. Masuda, R. Tanaka, A. Ganesan, T. Doi, Systematic Analysis of the Relationship among 3D Structure, Bioactivity, and Membrane Permeability of PF1171F, a Cyclic Hexapeptide with Paralyzing Effects on Silkworms, J. Org. Chem. 2017, 82(21), 11447-11463.  doi:10.1021/acs.joc.7b01975
  3. H. Tsukamoto, S. Hanada, K. Kumasaka, N. Kagaya, M. Izumikawa, K. Shin-ya, T. Doi, Synthesis of Spiromamakone A Benzo Analogues via Double Oxa-Michael Addition of 1,8-Dihydroxynaphthalene, Org. Lett. 2016, 18(19), 4848-4851.  doi: 10.1021/acs.orglett.6b02328
  4. H. Sato, M. Yoshida, H. Murase, H. Nakagawa, T. Doi, Combinatorial Solid-Phase Synthesis and Biological Evaluation of Cyclodepsipeptide Destruxin B as a Negative Regulator for Osteoclast Morphology, ACS Comb. Sci. 2016, 18(9), 590-595.  doi: 10.1021/acscombsci.6b00076
  5. Y. Masuda, K. Aoyama, M. Yoshida, K. Kobayashi, T. Ohshiro, H. Tomoda, T. Doi, Design, Synthesis, and Biological Evaluation of Beauveriolide Analogues Bearing Photoreactive Amino Acids, Chem. Pharm. Bull. 2016, 64(7), 754-765.  doi: 10.1248/cpb.c16-00095
  6. M. Yoshida, K. Sasahara, T. Doi, Total synthesis of cyclodepsipeptide spiruchostatin A on silyl-linked polymer-support, Tetrahedron 2015, 71(49), 7647-7653.  doi: 10.1016/j.tet.2015.07.064
  7. K. Fujiwara, H. Tsukamoto, M. Izumikawa, T. Hosoya, N. Kagaya, M. Takagi, H. Yamamura, M. Hayakawa, K. Shin-Ya, T. Doi, Total Synthesis and Structure Determination of JBIR-108―A 2-Hydroxy-2-(1-hydroxyethyl)-2,3-dihydro-3(2H)-furanone Isolated from Streptomyces gramineus IR087Pi-4, J. Org. Chem. 2015, 80(1), 114–132. doi: 10.1021/jo502198y
  8. M. Yoshida, N. Sekioka, M. Izumikawa, I. Kozone, M. Takagi, K. Shin-ya, T. Doi, Total Synthesis and Structure Elucidation of JBIR-39: A Linear Hexapeptide Possessing Piperazic Acid and γ-Hydroxypiperazic Acid Residues, Chem. Eur. J. 2015, 21(7), 3031–3041. doi: 10.1002/chem.201406020
  9. S. Fuse, H. Koinuma, A. Kimbara, M. Izumikawa, Y. Mifune, H. He, K. Shin-ya, T. Takahashi, T. Doi, Total Synthesis and Stereochemistry Revision of Mannopeptimycin Aglycone, J. Am. Chem. Soc. 2014, 136(34), 12011–12017. doi: 10.1021/ja505105t
  10. T. Doi, M. Yoshida, K. Ohsawa, K. Shin-ya, M. Takagi, Y. Uekusa, T. Yamaguchi, K. Kato, T. Hirokawa, T. Natsume, Total Synthesis and Characterization of Thielocin B1 as a Protein-Protein Interaction Inhibitor of PAC3 Homodimer, Chem. Sci. 2014, 5, 1860–1868. doi: 10.1039/C3SC53237B
  1. 増田裕一,土井隆行,生物活性環状ペプチドPF1171F類とapratoxin Cの全合成と三次元構造解析,化学工業,2016, 67(10), 738-745.
  2. 土井隆行,吉田将人,柴田和朗,テロメスタチンの全合成と類縁体合成,有合化,2015, 73(1), 7–17.
  3. T. Doi, “Synthesis of the Biologically Active Natural Product Cyclodepsipeptides Apratoxin A and Its Analogues”, Chem. Pharm. Bull., 2014, 62(8), 735-743.
Activities in Academic Societies
The Pharmaceutical Society of Japan, The Chemical Society of Japan, The Society of Synthetic Organic Chemistry, Japan, The Japanese Peptide Society, Kinki Chemical Society, Japanese Society for Chemical Biology
Advanced Molecular and Chemical Life Sciences

Recent Activities

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