GO TOP

Field

Molecular and Chemical Life Science :
Cooperative faculties

Research

JAPANESE
Professor NAKAYAMA Keiko
Campus Seiryo campus
Laboratory Cellular Function
Tel +81-22-717-8227
E-mail nakayak2＠med.tohoku.ac.jp
Website http://www.devgen.med.tohoku.ac.jp/
Google Scholar

Our body is composed of cells which have same genomic information, but they play different roles. On the other hand, each human beings have different genomic information, but we share features and characters of human beings. How do we accomplish such a great thing?

Career
1986 MD, Tokyo Medical and Dental University
1990 PhD, Graduate School of Medicine, Tokyo Medical and Dental University
1990 Postdoctoral Fellow, Washington University, USA
1997 Assistant Professor, Medical Institute of Bioregulation, Kyushu University
2001 Professor, School of Medicine, Tohoku University
Selected Publications
  1. TGF-β-Induced Proliferative Arrest Mediated by TRIM26-Dependent TAF7 Degradation and Its Antagonism by MYC. Nakagawa T, et al. Mol Cell Biol. doi: 10.1128/MCB.00449-17. [Epub ahead of print]
  2. Protein-arginine deiminase 2 suppresses proliferation of colon cancer cells through protein citrullination. Funayama R et al. Cancer Sci. 108:713 (2017)
  3. Lack of Transcription Triggers H3K27me3 Accumulation in the Gene Body. Hosogane M, et al. Cell Rep. 16: 696 (2016)
  4. Ras-induced changes in H3K27me3 occur after those in transcriptional activity. Hosogane M, et al. PLoS Genet. 9: e1003698 (2013).
Activities in Academic Societies
The Molecular Biology Society of Japan
Japanese Cancer Association

Recent Activities

We analyze molecular functions of cell cycle regulators by biochemistry, cellular biology, and gene-engineered mice. We frequently find interesting phenotypes in gene-engineered mice, which we did not expected. That means we do not have enough knowledge and imaginary skill to understand the world of nature. We are also trying to understand the mechanisms of diseases using clinical samples. 

Message to Students

Doing research is an active and free play. You verify what you think, and you evaluate your results by yourself. Let’s take the first step in your research. 

Research