GO TOP

Field

Molecular and Chemical Life Science :
Chemical Biology

Research

Assistant Professor TOMOSHIGE Shusuke
Campus Katahira campus
Laboratory Bioactive Molecules
Tel +81-22-217-6198
E-mail stomoshi@tohoku.ac.jp
Website https://www.agri.tohoku.ac.jp/ishikawa-lab/index.html
Google Scholar
ORCID
 
Shusuke Tomoshige completed his Ph.D. in pharmaceutical sciences at The University of Tokyo, Japan, in 2016 under the supervision of Prof. Yuichi Hashimoto. After his postdoctoral training for two years at University of Notre Dame, USA, under the guidance of Prof. Shahriar Mobashery, he joined Tokyo University of Science, Japan. Since September 2019, He has been appointed as an assistant professor at the Graduate School of Life Sciences, Tohoku University, Japan, working with Prof. Minoru Ishikawa.
Career
2006 - 2011  Undergrad. Student, Department of Applied Chemistry & Biotechnology, Chiba University
2011 - 2016  Ph.D. Student, Graduate School of Pharmaceutical Science, University of Tokyo
2016 - 2018  Postdoctoral Researcher, Department of Chemistry & Biochemistry, University of Notre Dame
2018 - 2019  Assistant Professor, Department of Applied Biological Science, Tokyo University of Science
2019 - Present  Assistant Professor, Graduate School of Life Sciences, Tohoku university
 
Selected Publications
  1. Haruki Kohatsu, Shogo Kamo, Shusuke Tomoshige, Kouji Kuramochi
    “Total Syntheses of Pyocyanin, Lavanducyanin, and Marinocyanins A and B”
    Org. Lett. 2019, 21, 7311-7314.
     
  2. Shusuke Tomoshige, David A. Dik, Masaaki Akabane-Nakata, Chinedu S. Madukoma, Jed F. Fisher, Joshua D. Shrout, Shahriar Mobashery
    “Total Syntheses of Bulgecin A, B and C and Bactericidal Potentiation of the β-Lactam Antibiotics”
    ACS Infect. Dis. 2018, 4, 860-867.
     
  3. Mijoon Lee, Maria T. Batuecas, Shusuke Tomoshige, Teresa Domínguez-Gil, Kiran V. Mahasenan, David A. Dik, Dusan Hesek, Claudia Millán, Isabel Usón, Elena Lastochkin, Juan A. Hermoso, Shahriar Mobashery
    “Exolytic and Endolytic Turnover of Peptidoglycan by Lytic Transglycosylase Slt of Pseudomonas aeruginosaProc. Natl. Acad. Sci., U.S.A, 2018, 115, 4393-4398.
     
  4. Shusuke Tomoshige, Sayaka Nomura, Kenji Ohgane, Yuichi Hashimoto, Minoru Ishikawa
    “Discovery of Small Molecules that Induce Degradation of Huntingtin”
    Angew. Chem. Int. Ed. 2017, 56, 11530–11533.
     
  5. Shusuke Tomoshige, Mikihiko Naito, Yuichi Hashimoto, Minoru Ishikawa
    “Degradation of HaloTag-fused Nuclear Proteins Using Bestatin-HaloTag Ligand Hybrid Molecules”
    Org. Biomol. Chem. 2015, 13, 9746–9750.
 
Activities in Academic Societies
Memberships: The Pharmaceutical Society of Japan, Japanese Society for Chemical Biology, and The Society of Synthetic Organic Chemistry, Japan.

Recent Activities

I have been working on the research on the degradation machinery of biopolymers (e.g. proteins and cell wall), especially ubiquitin-proteasome system (UPS). Recently, we have achieved the targeted protein knockdown of proteins involved in neurodegenerative disorders mediated by small molecules harnessing a ubiquitin ligase (E3), an enzyme conjugating ubiquitin to substrates, and currently are making an effort to expand the scope of the compounds. Also, I am challenging to develop the novel small molecules hijacking another E3.

Message to Students

The Ishikawa group (Bioactive Molecules lab.) has just started in April, 2019 and we are pleased to work with the Tohoku University members. Our group carry out interdisciplinary studies integrating computation, molecular biology, and organic syntheses of medically important bioactive molecules. Motivated students are highly welcomed to commence their post-graduate programs in our group. Feel free to contact me by e-mail if you are weighing joining our group.