Molecular and Chemical Life Science :
Chemical Biology


Assistant Professor TOMOSHIGE Shusuke
Campus Katahira campus
Laboratory Bioactive Molecules
Tel +81-22-217-6198
E-mail stomoshi@tohoku.ac.jp
Website https://www.agri.tohoku.ac.jp/ishikawa-lab/index.html https://stomoshi.studio.site/
Google Scholar
Shusuke Tomoshige completed his Ph.D. in pharmaceutical sciences at The University of Tokyo, Japan, in 2016 under the supervision of Prof. Yuichi Hashimoto. After his postdoctoral training for two years at University of Notre Dame, USA, under the guidance of Prof. Shahriar Mobashery, he joined Tokyo University of Science, Japan. Since September 2019, He has been appointed as an assistant professor at the Graduate School of Life Sciences, Tohoku University, Japan, working with Prof. Minoru Ishikawa.
2006 - 2011  Undergrad. Student, Department of Applied Chemistry & Biotechnology, Chiba University
2011 - 2016  Ph.D. Student, Graduate School of Pharmaceutical Science, University of Tokyo
2016 - 2018  Postdoctoral Researcher, Department of Chemistry & Biochemistry, University of Notre Dame
2018 - 2019  Assistant Professor, Department of Applied Biological Science, Tokyo University of Science
2019 - Present  Assistant Professor, Graduate School of Life Sciences, Tohoku university
Selected Publications
  1. Keigo Hirai, Hiroko Yamashita, Shusuke Tomoshige,* Yugo Mishima, Tatsuya Niwa, Kenji Ohgane, Mayumi Ishii, Kayoko Kanamitsu, Yui Ikemi, Shinsaku Nakagawa, Hideki Taguchi, Shinichi Sato, Yuichi Hashimoto, Minoru Ishikawa*
    “Conversion of A PROTAC Mutant Huntingtin Degrader into Small-molecule Hydrophobic Tags Focusing on Druglike Properties”
    ACS Med. Chem. Lett. 2022, 16, 396-402.
  2. Shusuke Tomoshige, Minoru Ishikawa* 
    “PROTACs and Other Chemical Protein Degradation Technologies for the Treatment of Neurodegenerative Disorders”
    Angew. Chem. Int. Ed. 2021, 60, 3346–3354.
  3. Hiroko Yamashita, Shusuke Tomoshige, Sayaka Nomura, Kenji Ohgane, Yuichi Hashimoto, Minoru Ishikawa*
    “Application of Protein Knockdown Strategy Targeting β-Sheet Structure to Multiple Disease-associated Polyglutamine Proteins”
    Bioorg. Med. Chem. 2020, 28, 115175.
  4. David A. Dik, Chinedu S. Madukoma, Shusuke Tomoshige, Choon Kim, Elena lastochkin, Bill Boggess, Jed F. Fisher, Joshua D. Shrout, Shahriar Mobashery*
    “Lytic Transglycosylases Slt, MltD and MltG of Pseudomonas aeruginosa as Targets of Bulgecin A in Potentiation of β-Lactam Antibiotics”
    ACS Chem. Biol. 2019. 14, 296-303.
  5. Shusuke Tomoshige, David A. Dik, Masaaki Akabane-Nakata, Chinedu S. Madukoma, Jed F. Fisher, Joshua D. Shrout, Shahriar Mobashery
    “Total Syntheses of Bulgecin A, B and C and Bactericidal Potentiation of the β-Lactam Antibiotics”
    ACS Infect. Dis. 2018, 4, 860-867.
  6. Mijoon Lee, Maria T. Batuecas, Shusuke Tomoshige, Teresa Domínguez-Gil, Kiran V. Mahasenan, David A. Dik, Dusan Hesek, Claudia Millán, Isabel Usón, Elena Lastochkin, Juan A. Hermoso, Shahriar Mobashery
    “Exolytic and Endolytic Turnover of Peptidoglycan by Lytic Transglycosylase Slt of Pseudomonas aeruginosaProc. Natl. Acad. Sci., U.S.A, 2018, 115, 4393-4398.
  7. Shusuke Tomoshige, Sayaka Nomura, Kenji Ohgane, Yuichi Hashimoto, Minoru Ishikawa
    “Discovery of Small Molecules that Induce Degradation of Huntingtin”
    Angew. Chem. Int. Ed. 2017, 56, 11530–11533.
  8. Shusuke Tomoshige, Mikihiko Naito, Yuichi Hashimoto, Minoru Ishikawa
    “Degradation of HaloTag-fused Nuclear Proteins Using Bestatin-HaloTag Ligand Hybrid Molecules”
    Org. Biomol. Chem. 2015, 13, 9746–9750.
Activities in Academic Societies
Memberships: The Pharmaceutical Society of Japan, Japanese Society for Chemical Biology, and The Society of Synthetic Organic Chemistry, Japan.

Recent Activities

I have been working on the methodology for chemical control of proteostasis (protein-homeostasis, e.g. degradation and folding). Recently, we have achieved the targeted protein degradation of proteins involved in neurodegenerative disorders mediated by small molecules harnessing a ubiquitin ligase (E3), an enzyme conjugating ubiquitin to substrates, and currently are making an effort to expand the scope of the compounds.

Message to Students

Our group carry out interdisciplinary studies integrating computation, molecular biology, and organic syntheses of medically important bioactive molecules. Motivated students are highly welcomed to commence their post-graduate programs in our group. Feel free to contact me by e-mail if you are weighing joining our group.