When I looked in a microscope and saw the dynamics of cellular structures for the first time, I found myself eager to see and learn more and more about the elaborate mechanisms behind the cellular behaviors. I enjoy reading books, eating at new restaurants, and spending quality time with my friends, family and colleagues.
Assistant Professor NINOMIYA Komaki
Campus | Aobayama campus |
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Laboratory |
Histogenetic Dynamics
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Tel | +81-22-795-6701 |
komaki.ninomiya.b5@tohoku.ac.jp |
Career |
Mar. 2016 B.Sc., Department of Biology, Faculty of Science, Tohoku University
Mar. 2021 Ph.D., Department of Molecular and Chemical Life Sciences, Graduate School of Life Sciences, Tohoku University Oct. 2019 - Apr. 2020 Intern, Mechanobiology Institute, National University of Singapore Apr. 2021 - Mar. 2022 Postdoctoral researcher, Graduate School of Life Sciences, Tohoku University Apr. 2020 - Mar.-2022 Research fellow, Japan Society for the Promotion of Science (DC and PD) Apr. 2022 - Present Assistant professor, Graduate School of Life Sciences, Tohoku University |
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Selected Publications |
Komaki Ninomiya, Kai Ohta, Ukyo Kawasaki, Shuhei Chiba, Takanari Inoue, Erina Kuranaga, Kazumasa Ohashi, and Kensaku Mizuno “Calcium influx promotes PLEKHG4B localization to cell-cell junctions and regulates the integrity of junctional actin filaments.” Molecular Biology of the Cell, 2024 Feb 1;35(2):ar24. , 2024
Komaki Ninomiya, Kai Ohta, Kazunari Yamashita, Kensaku Mizuno, and Kazumasa Ohashi “PLEKHG4B enables actin cytoskeletal remodeling during epithelial cell-cell junction formation.” Journal of Cell Science, 27;134(2): jcs249078, 2021
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Activities in Academic Societies |
Japan Society for Cell Biology
The Molecular Biology Society of Japan
Japanese Biochemical Society
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Recent Activities
I studied actin cytoskeletal dynamics focusing on cell-cell junction formation during my Ph.D. course. Cell-cell junction formation is a multistep process that involves actin cytoskeletal reorganization and the regulation of actin-dependent contractility, but the underlying molecular mechanism still has been elusive. I revealed that a Rho-GEF named PLEKHG4B is the novel player in the epithelial cell-cell junction formation, particularly in the step of regulating the contractility during junction maturation. I would like to continue investigating the mechanisms to achieve the dynamic cellular behaviors during tissue morphogenesis in vivo.