When I looked in a microscope and saw the dynamics of cellular structures for the first time, I found myself eager to see and learn more and more about the elaborate mechanisms behind the cellular behaviors. I enjoy reading books, eating at new restaurants, and spending quality time with my friends, family and colleagues.
Assistant Professor NINOMIYA Komaki
Mar. 2016 B.Sc., Department of Biology, Faculty of Science, Tohoku University
Mar. 2021 Ph.D., Department of Molecular and Chemical Life Sciences, Graduate School of Life Sciences, Tohoku University
Oct. 2019 - Apr. 2020 Intern, Mechanobiology Institute, National University of Singapore
Apr. 2021 - Mar. 2022 Postdoctoral researcher, Graduate School of Life Sciences, Tohoku University
Apr. 2020 - Mar.-2022 Research fellow, Japan Society for the Promotion of Science (DC and PD)
Apr. 2022 - Present Assistant professor, Graduate School of Life Sciences, Tohoku University
Ninomiya, Komaki, Ohta, Kai, Yamashita, Kazunari, Mizuno, Kensaku, and Ohashi, Kazumasa “PLEKHG4B enables actin cytoskeletal remodeling during epithelial cell-cell junction formation.” Journal of Cell Science, 27;134(2): jcs249078, 2021
|Activities in Academic Societies||
Japan Society for Cell Biology
The Molecular Biology Society of Japan
Japanese Biochemical Society
I studied actin cytoskeletal dynamics focusing on cell-cell junction formation during my Ph.D. course. Cell-cell junction formation is a multistep process that involves actin cytoskeletal reorganization and the regulation of actin-dependent contractility, but the underlying molecular mechanism still has been elusive. I revealed that a Rho-GEF named PLEKHG4B is the novel player in the epithelial cell-cell junction formation, particularly in the step of regulating the contractility during junction maturation. I would like to continue investigating the mechanisms to achieve the dynamic cellular behaviors during tissue morphogenesis in vivo.