Molecular and Chemical Life Science :
Multilevel Biomolecular Structure and Dynamics


Associate Professor HAMAGUCHI Tasuku
Campus Katahira campus
Laboratory Structural Mechanism Research and Development
2022-present   Associate professor, IMRAM, Tohoku university
2017-2022         Researcher, SPring-8, RIKEN
2013-2017         Specially appointed research associate, Osaka city university
2012-2013         Specially appointed lecturer, Osaka city university
2010-2012         Specially appointed research associate, Osaka city university
2010                  PhD in Science, Osaka city university
2005                  B.A in Science, Osaka city university
Selected Publications
Tasuku Hamaguchi, Keisuke Kawakami, Kyoko Shinzawa-Itoh, Natsuko Inoue-Kashino, Shigeru Itoh, Kentaro Ifuku, Eiki Yamashita, Kou Maeda, Koji Yonekura, and Yasuhiro Kashino. 2021. “Structure of the far-red light utilizing photosystem I of Acaryochloris marina.Nature Communications 12 (1): 2333
Yu, Huaxin, Tasuku Hamaguchi (equally contribution), Yoshiki Nakajima, Koji Kato, Keisuke Kawakami, Fusamichi Akita, Koji Yonekura, and Jian-Ren Shen. 2021. “Cryo-EM structure of monomeric photosystem II at 2.78 Å resolution reveals factors important for the formation of dimer.” Biochimica et Biophysica Acta (BBA) - Bioenergetics 1862 (10): 148471
Kato, Koji, Naoyuki Miyazaki, Tasuku Hamaguchi (equally contribution), Yoshiki Nakajima, Fusamichi Akita, Koji Yonekura, and Jian-Ren Shen. 2021. “High-resolution cryo-EM structure of photosystem II reveals damage from high-dose electron beams.” Communications Biology 4 (1): 382
Tasuku Hamaguchi, and Koji Yonekura. 2020. “Tidy up cryo-EM sample grids with 3D printed tools.” Journal of Structural Biology 209 (1): 107414
Tasuku Hamaguchi, Masaru Kawakami, Hidemitsu Furukawa, and Makoto Miyata. 2019. “Identification of novel protein domain for sialyloligosaccharide binding essential to Mycoplasma mobile gliding.” FEMS Microbiology Letters 366 (3).
Tasuku Hamaguchi, Saori Maki-Yonekura, Hisashi Naitow, Yoshinori Matsuura, Tetsuya Ishikawa, and Koji Yonekura. 2019. “A new cryo-EM system for single particle analysis.” Journal of Structural Biology 207 (1): 40–48
Activities in Academic Societies
The Biophysical Society of Japan
Advanced molecular and chemical biology seminar III (Multilevel biomolecular structure and dynamics)

Recent Activities

Cryo-electron microscopy (cryo-EM) allows observation of biological samples such as proteins and cells embedded in a thin layer of vitreous ice and determination of their three-dimensional structures. In our laboratory, I am conducting structural analyses and also developing measurement techniques by using advanced cryo-EM.

Message to Students

By looking into a small world using an electron microscope, we can obtain information that no one has ever seen before, and reveal phenomena that have long been hidden in a mystery.