GO TOP

Field

Molecular and Chemical Life Science :
Molecular and Network Genomics

Research

JAPANESE
Associate Professor ICHINOSE Toshiharu (C)
Campus Aobayama campus
Laboratory Evolutionary Genomics
Tel +81-22-795-5265
E-mail toshiharu.ichinose.c1＠tohoku.ac.jp
Website https://www2.fris.tohoku.ac.jp/~ichinose/ja/index.html
Google Scholar
Career
2005-2009    The University of Tokyo, Japan (Faculty of Science, Department of Biological Science, Bachelor’s degree)
2009- 2011    The University of Tokyo, Japan (Graduate School of Science, Department of Biophysics and Biochemistry, Master’s degree)
2011-2014    Max Planck Institute of Neurobiology, Germany (PhD student)
2014-2015    Tohoku University, Japan (Graduate School of Life Sciences, Department of integrative Life Sciences, PhD)
2016    Research Associate (Tohoku University)
2017-2019    Post-doc (JSPS Post-doctoral Researcher (PD))
2019-2024    Assistant Professor (Tohoku University)
2024-    Associate Professor (Tohoku University)
 
Selected Publications
  1. *Takada Y, Ichinose T, Fuse N, Saito K, Ikeda-Ohtsubo W, Tanimoto H, *Hori M. (2025) “Gut microbiota-mediated lipid accumulation as a driver of evolutionary adaptation to blue light toxicity in Drosophila”. Commun. Biol. doi: 10.1038/s42003-025-08348.
  2. Saito K, Kanno M, Tanimoto H, *Ichinose T. (2025) “Ecdysteroid-DopEcR signaling in neuronal and midgut cells mediates toxin avoidance and detoxification in Drosophila”. Curr Biol. doi: 10.1016/j.cub.2025.06.02. 
  3. *Ichinose T, Tanimoto H. (2025) “Profiling translation in the nervous system”. J Biochem. 2025;1-8. doi:10.1093/jb/mvae096.
  4. *Ichinose T, Kondo S, Kanno M, Shichino Y, Mito M, Iwasaki S, *Tanimoto H. (2024) “Translational regulation enhances distinction of cell types in the nervous system”. eLife. 12:90713. doi: 10.7554/eLife.90713
  5. *Lynn K, Ichinose T, Tanimoto H. (2024) “Peer-induced quiescence of male Drosophila melanogaster following copulation”. Front. Behav. Neurosci. 18:1414029. doi: 10.3389/fnbeh.2024.1414029.
  6. Venkatasubramani AV, Ichinose T, Kanno M, Forne I, Tanimoto H, *Peleg S, *Imhof A. (2023) “The fruit fly acetyltransferase chameau promotes starvation resilience at the expense of longevity”. EMBO Reports. 24:e57023. doi: 10.15252/embr.202357023.
  7. Kanno M, Hiramatsu S, Kondo S, Tanimoto H, *Ichinose T. (2021) “Voluntary intake of psychoactive substances is regulated by the dopamine receptor Dop1R1 in Drosophila”. Sci. Rep. 11(1):3432. doi: 10.1038/s41598-021-82813-0.
  8. *+Ichinose T, +Kanno M, Wu H, Yamagata N, Sun H, Abe A, *Tanimoto H. (2021) “Mushroom body output differentiates memory processes and distinct memory-guided behaviors”. Curr. Biol. 31, 1-9. doi: 10.1016/j.cub.2020.12.032.
  9. Sun H, Nishioka T, Hiramatsu S, Kondo S, Amano M, Kaibuchi K, *+Ichinose T, *+Tanimoto H. (2020) “Dopamine receptor Dop1R2 stabilizes appetitive olfactory memory through the Raf/MAPK pathway in Drosophila”. J. Neurosci. 40(14):2935-2942. doi: 10.1523/JNEUROSCI.1572-19.2020.
  10. Ichinose T, Tanimoto H, *Yamagata N. (2017) “Behavioral modulation by spontaneous activity of dopamine neurons”. Front. Syst. Neurosci. 11:88 doi: 10.3389/fnsys.2017.00088.
  11. *Ichinose T, *Tanimoto H. (2016) “Dynamics of memory-guided choice behavior in Drosophila”. Proc Jpn Acad Ser B. 92(8):346-357. doi: 10.2183/pjab.92.346.
  12. Vogt K, Aso Y, Hige T, Knapek S, Ichinose T, Friedrich AB, Turner GC, *Rubin GM, *Tanimoto H. (2016) “Direct neural pathways convey distinct visual information to Drosophila mushroom bodies”. eLife. 5:e14009. doi: 10.7554/eLife.14009.
  13. Ichinose T, Aso Y, Yamagata N, Abe A, Rubin GM, *Tanimoto H. (2015) “Reward signal in a recurrent circuit drives appetitive long-term memory formation”. eLife. 4:e10719. doi: 10.7554/eLife.10719.
  14. *Yamagata N, Ichinose T, Aso Y, Plaçais PY, Friedrich AB, Sima RJ, Preat T, *Rubin GM, *Tanimoto H. (2015) “Distinct dopamine neurons mediate reward signals for short- and long-term memories”. Proc Natl Acad Sci USA. 112(2): 578-583. doi: 10.1073/pnas.1421930112.
  15. *Aso Y, Sitaraman D, Ichinose T, Kaun KR, Vogt K, Belliart-Guérin G, Plaçais PY, Robie AA, Yamagata N, Schnaitmann C, Rowell WJ, Johnston RM, Ngo TT, Chen N, Korff W, Nitabach M, Heberlein U, Preat T, Branson K, Tanimoto H, *Rubin GM. (2014) “Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila”. eLife. 3:e04580. doi: 10.7554/eLife.04580.
     
Activities in Academic Societies
The Japan Neuroscience Society, The RNA society of Japan, Japanese society for Chronobiology
Teaching
Biology A, Biology B (Future Global Program)

Recent Activities

For the nervous system to perform its diverse functions and adapt through plastic changes, gene expression must be tightly regulated at both transcriptional and translational stages. Our work centers on understanding how translational control influences brain functions and behaviors. We approach this by combining genome-wide profiling of translation with genetic engineering and behavioral studies using fruit fly Drosophila.

Message to Students

Our lab is part of the Graduate School of Life Sciences, but we conduct our research at the Frontier Research Institute for Interdisciplinary Sciences (FRIS) on the Aobayama campus. FRIS is a unique environment where scientists from not only life sciences but also other fields, including physics, chemistry, and engineering, come together to push the boundaries of interdisciplinary research. Graduate students can carry out research projects at FRIS while belonging to the Graduate School of Life Sciences, where they can earn master’s and doctoral degrees. We welcome inquiries from prospective students who are interested in the nervous system, animal behavior, translational control and omics analyses.

Research