【タイトル】
Integrating Genetic and Epigenetic Information During Programmed Genome Rearrangement in Tetrahymena

 

 

【使用言語】

英語

 

【日時】
2026年6月5日(金）16:00~17:30

 

【会場】
自然共生実験棟クリエィティブスペース1F (ハイブリッド開催）
地図：https://www.tohoku.ac.jp/map/ja/?f=KH_D06

 

【講義要旨】

Programmed DNA elimination (PDE) in Tetrahymena is a model of transgenerational epigenetic inheritance. During sexual reproduction, a new somatic macronucleus (MAC) develops from the germline micronucleus (MIC), eliminating ~50% of the genome, including most transposable elements. PDE is guided by Piwi-associated ~29-nt RNAs (scnRNAs) through a genome subtraction process. scnRNAs produced from the MIC are filtered in the parental MAC, where sequences matching the somatic genome are removed. The remaining scnRNAs direct elimination in the developing MAC. We identify an additional, genetically encoded pathway of scnRNA production. Highly repetitive MIC-limited sequences (MLSs), mainly at chromosome ends, act as major scnRNA sources. Although representing only ~2% of the MIC genome, they generate ~25% of scnRNAs and can target ~60% of eliminated sequences. These results support a two-layer model combining soma-to-soma epigenetic inheritance and germline to-soma genetic control. Together, these pathways shape the streamlined somatic genome and provide insight into parallels with piRNA-mediated transposon silencing in animals.

 

【参加登録・視聴URL】
https://zoom.us/meeting/register/BVvfZtdaTTONEHLS4a4Www

 

 

お問い合わせ先
杉本 亜砂子 （生命科学研究科 発生ダイナミクス分野）
Prof. SUGIMOTO Asako, Developmental Dynamics
E-mail：asako.sugimoto.d1@tohoku.ac.jp / TEL：022-217-6194