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研究分野

分子化学生物学専攻 :
ケミカルバイオロジー講座

研究

Elshamy Noha

ENGLISH
助教 Elshamy Noha
キャンパス 片平 キャンパス
所属研究室 応用生命分子解析
連絡先 022-217-6206
E-mail elshamy.noha.c1＠tohoku.ac.jp
Google Scholar
 
Gram-negative pathogens have increasingly developed resistance to antibiotics in the last decade. Using Structural Biology, I study the structure of bacterial virulence factors and membrane secretion systems to understand the mechanisms of infection and propose new targets for antimicrobial development.
経歴
May 2026 – current       Assistant Professor, Graduate School of Life Sciences, Tohoku University
October 2025 – March 2026   Specially Appointed Assistant Professor, Research Institute for Microbial Diseases, Osaka University
June 2023 – June 2024    JSPS fellow, Graduate School of Life Sciences, Tohoku University
June 2022 – current       Assistant Professor, Faculty of Pharmacy, Cairo University, Egypt
December 2016 – May 2022     Lecturer, Faculty of Pharmacy, Cairo University, Egypt
November 2016   PhD in Microbiology and Immunology, Faculty of Pharmacy, Cairo University, Egypt
August 2015 – April 2016   Fulbright Fellow, Harvard Medical School, Boston, USA
November 2013 – December 2016     Assistant Lecturer, Faculty of Pharmacy, Cairo University, Egypt
October 2013     Master’s in Microbiology and Immunology, Faculty of Pharmacy, Cairo University, Egypt
April 2011 – November 2013   Teaching Assistant, Faculty of Pharmacy, Cairo University, Egypt
May 2010   Bachelor’s in Pharmaceutical Sciences, Faculty of Pharmacy, Cairo University, Egypt
著書・論文
  1. Alahmar AJ, Elhosseiny NM, Mahmoud RR, Attia AS. Transcriptional regulator NtrC modulates nitrogen assimilation, virulence, and the extracellular glutamine synthetase activity in Acinetobacter baumannii. PLoS One, 23;21(1): e0341569 (2026)
  2. Othman D, Elhosseiny NM, Eltayeb WN, Attia AS. (2024). The Moraxella catarrhalis AdhC–FghA system is important for formaldehyde detoxification and protection against pulmonary clearance. Med Microbiol Immunol., 213(1):3 (2024)
  3. Elhosseiny NM, Samir TM, Ali AA, El-kholy AA, Attia AS. Development of an immunochromatographic strip using conjugated gold nanoparticles for the rapid detection of Klebsiella Pneumoniae causing neonatal sepsis. Pharmaceutics, 13(8):1141 (2021)
  4. Elhosseiny NM, Elhezawy NB, Sayed RM, Khattab MS, El Far MY, Attia AS. γ-Glutamyltransferase as a Novel Virulence Factor of Acinetobacter baumannii Inducing Alveolar Wall Destruction and Renal Damage in Systemic Disease. J Infect Dis., 222(5):871-879 (2020)
  5. Sanchez-Larrayoz AF, Elhosseiny NM, Chevrette MG, Fu Y, Giunta P, Spallanzani RG, Ravi K, Pier GB, Lory S, Maira-Litran T. Complexity of Complement Resistance Factors Expressed by Acinetobacter baumannii Needed for Survival in Human Serum. J Immunol., 199(8):2803-2814 (2017)
 
Note: selected papers have been published under the academic name Elhosseiny.

最近の研究について

Bacterial secretion systems:
I have recently focused on sequence and structural variability in the outer membrane component of the Type II Secretion System (T2SS) in Gram-negative bacterial. My current goal is to understand the correlation between domain sequence length and structural organization, with substrate recruitment and the secretion mechanism. I use techniques such as genomic mutagenesis, functional assays and cryo-EM single particle analysis to understand how the outer membrane component of the T2SS enables the secretion of virulence protein.
 
Lipoprotein membrane localization:
The lipoprotein outer membrane localization machinery plays an important role in the processing and transport of lipoproteins that are important for membrane structure, as well as displaying virulence-related proteins on the surface of the cell, where it engages with host receptors. Since this machinery is vital for the life of the microbial cell, it represents a good target for antimicrobial development. Using X-ray crystallography, I determine the structure of the components of the lipoprotein localization system and employ computational drug design to test for lead compounds for antimicrobial development.
 

メッセージ

Recent advances in the field of structural biology have made it possible to visualize entire cellular processes as they happen in real time. By combining Microbiology and Structural Biology, I hope that together we would be able to provide the knowledge needed about microbial infections well in advance, before the next “Covid” situation threatens us again.

研究