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Prof. David Ron 講演会 Protein folding homeostasis in the Endoplasmic Reticulum

Prof. David Ron 講演会 Protein folding homeostasis in the Endoplasmic Reticulum

題目:Protein folding homeostasis in the Endoplasmic Reticulum

2014.03.05 11:32
17:00~18:30
片平キャンパス生命科学プロジェクト総合研究棟1F 104講義室
Prof. David Ron  (University of Cambridge)
多元研・生体分子構造研究分野
稲葉 謙次 TEL: 022-217-5604
E-mail: kinaba@tagen.tohoku.ac.jp

(概要)
The endoplasmic reticulum is distinct from other protein folding
compartments not only by certain biochemical peculiarities (N-linked
glycosylation, disulfide bond formation, proline hydroxylation, etc.) but also
by the unusual high turnover of its clients and by their fluctuating load.
These features, prominent in professional secretory cells, have favoured the
evolution of cellular adaptations that match the organelle’s capacity to process
client proteins with the demands placed on it. Some details of these
adaptations will be presented and discussed.