【開催日時・Date】
2025.5.13(TUE) 16:00～
2025.5.13(TUE) 16:00～
【講師・Speaker】
明楽隆志博⼠（Dr. Takashi Akera）
明楽隆志博⼠（Dr. Takashi Akera）
⽶国国⽴衛⽣研究所
NIH (National Institute of Health)
NIH (National Institute of Health)
【会場・Venue】
ハイブリッド開催（Hybrid）
片平・生命科学プロジェクト研究棟講義室AB
Life Sciences Project Research Laboratory, Lecture hall
【事前登録・Pre-registration】
Zoom link
https://us06web.zoom.us/meeting/register/WLlLNgYET0iOM-qP2KkOIg
片平・生命科学プロジェクト研究棟講義室AB
Life Sciences Project Research Laboratory, Lecture hall
【事前登録・Pre-registration】
Zoom link
https://us06web.zoom.us/meeting/register/WLlLNgYET0iOM-qP2KkOIg
【使用言語・Language】
English
English
【題目・Title】
＜第⼀部＞ 16:00~17:10
The impact of non-Mendelian transmission on reproduction and speciation
メンデルの法則に反する遺伝様式が有性⽣殖と種分化に与える影響
The impact of non-Mendelian transmission on reproduction and speciation
メンデルの法則に反する遺伝様式が有性⽣殖と種分化に与える影響
Abstract: Mendel’s Law of Segregation states that each allele has an equal chance to transmit
to the next generation. However, this law can be violated by selfish genetic elements, which
manipulate the production of gametes (e.g., eggs, sperm) to increase their own transmission
rate. This genetic cheating in meiosis, meiotic drive, has significant impacts on Genetics,
Evolution, and Reproduction because the cheating alters transmission ratios and manipulates
gametogenesis, often leading to fertility issues and genetic disorders (e.g., Down Syndrome). In
female meiosis, selfish elements bias their transmission by preferentially segregating to the egg.
However, it remains largely unknown how these elements bias their segregation to the egg
especially in animals. My lab uses mouse models and cell biological approaches to visualize
selfish elements to reveal how these elements manipulate female meiosis to preferentially
segregate to the egg. I will discuss our recent findings on the mechanisms of meiotic drive and
how it impacts mammalian reproduction and speciation.
to the next generation. However, this law can be violated by selfish genetic elements, which
manipulate the production of gametes (e.g., eggs, sperm) to increase their own transmission
rate. This genetic cheating in meiosis, meiotic drive, has significant impacts on Genetics,
Evolution, and Reproduction because the cheating alters transmission ratios and manipulates
gametogenesis, often leading to fertility issues and genetic disorders (e.g., Down Syndrome). In
female meiosis, selfish elements bias their transmission by preferentially segregating to the egg.
However, it remains largely unknown how these elements bias their segregation to the egg
especially in animals. My lab uses mouse models and cell biological approaches to visualize
selfish elements to reveal how these elements manipulate female meiosis to preferentially
segregate to the egg. I will discuss our recent findings on the mechanisms of meiotic drive and
how it impacts mammalian reproduction and speciation.
References: Clark FE, Akera T., et.al, . An egg sabotaging mechanism drives non-Mendelian
transmission in mice. Curr Biol. 9;34(17):3845-3854 (2024)
El Yakoubi W and Akera T. Condensin dysfunction is a reproductive isolating barrier in mice.
Nature 623(7986):347-355 (2023)
transmission in mice. Curr Biol. 9;34(17):3845-3854 (2024)
El Yakoubi W and Akera T. Condensin dysfunction is a reproductive isolating barrier in mice.
Nature 623(7986):347-355 (2023)
＜第⼆部＞A career talk 17:10~18:00
~pursuing a childhood dream of going to space, while running a lab in the US~
海外独⽴そして宇宙への挑戦
~pursuing a childhood dream of going to space, while running a lab in the US~
海外独⽴そして宇宙への挑戦
Abstract: Career path after acquiring a PhD degree is becoming increasing diverse. During
this and Europe to launch my own laboratory. While pursuing basic science in the lab, I
never forgot my childhood dream to go to space. I will also discuss how I balanced my real
life as a PI while applying for the astronaut position to achieve my dream and what I
eventually got from this experience even though I was not selected. I wish this presentation
would provide some hope to junior scientists who are deciding their career trajectories.
this and Europe to launch my own laboratory. While pursuing basic science in the lab, I
never forgot my childhood dream to go to space. I will also discuss how I balanced my real
life as a PI while applying for the astronaut position to achieve my dream and what I
eventually got from this experience even though I was not selected. I wish this presentation
would provide some hope to junior scientists who are deciding their career trajectories.
Contact
生命科学研究科 発生ダイナミクス分野
Grad. Sch. of Life Sciences, Developmental Dynamics
杉本亜砂子
Asako Sugimoto
E-mail：asako.sugimoto.d1(at)tohoku.ac.jp
生命科学研究科 発生ダイナミクス分野
Grad. Sch. of Life Sciences, Developmental Dynamics
杉本亜砂子
Asako Sugimoto
E-mail：asako.sugimoto.d1(at)tohoku.ac.jp