脳生命統御科学専攻 :


田口 友彦

教授 田口 友彦
キャンパス 青葉山 キャンパス
所属研究室 細胞小器官疾患学
連絡先 022-795-6676
E-mail tomohiko.taguchi.b8@tohoku.ac.jp
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1992年           東京大学理学部生物化学科卒業
1994年        東京大学大学院理学系研究科生物化学科(修士課程)修了
1997年        東京大学大学院理学系研究科生物化学科(博士課程)修了
1994-1997年    日本学術振興会 特別研究員(DC1)
1997-1999年    理化学研究所 基礎科学特別研究員
1999-2004年    エール大学(米国)医学部細胞生物学部門
1999-2001年    日本学術振興会 海外特別研究員
2004-2007年    大阪大学大学院医学系研究科 特任助教授
2007-2008年    大阪大学大学院医学系研究科 特任准教授
2008-2010年    クイーンズランド大学(豪州)分子細胞生物学研究所 上級研究員
2011-2018年    東京大学大学院薬学系研究科 特任准教授
2018年-       東北大学大学院生命科学研究科 教授

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Sci Rep. 11, 11996
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Taguchi, T., et al. (2021). STING operation at the ER/Golgi interface.
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Taguchi, T and Mukai, K. (2019) Innate immunity signalling and membrane trafficking.
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Hansen, A. L., et al. (2019). STING palmitoylation as a therapeutic target.
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Tanigawa, K., et al. (2019). SNX9 determines the surface levels of integrin β1 in vascular endothelial cells: Implication in poor prognosis of human colorectal cancers overexpressing SNX9.
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Hansen, A. L., et al. (2018). Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling.
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Takahashi, S., et al. (2018). Development of a Series of Practical Fluorescent Chemical Tools To Measure pH Values in Living Samples.
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Takahashi, M., et al. (2015). Ag/FeCo/Ag Core/Shell/Shell Magnetic Nanoparticles with Plasmonic Imaging Capability.
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Matsudaira, T., et al. (2013). SMAP2 regulates retrograde transport from recycling endosomes to the Golgi.
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Taguchi, T. (2013). Emerging roles of recycling endosomes.
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Taguchi, T., et al. (2012). [Emerging roles of intracellular phosphatidylserine (PS) in membrane traffic].
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Hieda, M., et al. (2012). The cytoplasmic tail of heparin-binding EGF-like growth factor regulates bidirectional intracellular trafficking between the plasma membrane and ER.
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 McKenzie, J. E., et al. (2012). Retromer Guides STxB and CD8-M6PR from Early to Recycling Endosomes, EHD1 Guides STxB from Recycling Endosome to Golgi.
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Lee, S., et al. (2012). Impaired retrograde membrane traffic through endosomes in a mutant CHO cell defective in phosphatidylserine synthesis.
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Taguchi, T., et al. (2011). Palmitoylation pilots ras to recycling endosomes.
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J. Biol. Chem. 275, 36029-36034.
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・自然免疫分子STINGの活性化がゴルジ体で起こること、そのメカニズムとしてゴルジ体膜で起こるSTINGのパルミトイル化脂質修飾が必須であることを明らかにしました(Mukai et al., Nat Commun 2016)。STINGは老化や生活習慣病による炎症、抗腫瘍免疫など幅広い生命現象に関与しており、STINGの活性化・不活性化の分子機構を理解することは、純粋なサイエンスとしての興味に加えて、人類の健康に大きく貢献するものと考えています。
・細胞小器官に固有に存在するリン脂質を利用した、細胞小器官に局在するタンパク質の同定法を開発しました(Matsudaira et al., Nat Commun 2017)。今後、細胞小器官膜の機能解明に多いに貢献することが期待される新手法です。